Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

Translational Psychiatry
J V Sanchez-MutM Esteller

Abstract

Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.

References

Feb 4, 2003·Nature Reviews. Neuroscience·Jacqueline N Wood, Jordan Grafman
May 24, 2003·Cerebral Cortex·Luca Muzio, Antonello Mallamaci
Feb 21, 2006·Annals of Neurology·Wendy R Galpern, Anthony E Lang
Dec 17, 2008·Neuron·Dohoon KimLi-Huei Tsai
Mar 25, 2009·Nature Reviews. Genetics·Howard Cedar, Yehudit Bergman
Jun 23, 2009·Genome Research·Martin KrzywinskiMarco A Marra
Sep 8, 2009·Methods : a Companion to Methods in Enzymology·Jason W BohlandPartha P Mitra
Oct 17, 2009·Lancet Neurology·Rocio G UrdinguioManel Esteller
Apr 12, 2011·Reviews in the Neurosciences·Carlos A Saura, Jorge Valero
May 20, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Juan SandovalManel Esteller
Aug 16, 2011·Genomics·Marina BibikovaRichard Shen
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Holger HeynManel Esteller
Oct 5, 2012·Genome Biology·Kasper D HansenRafael A Irizarry
Dec 19, 2012·Epigenomics·Charles Vinson, Raghunath Chatterjee
Feb 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Younhee KoNathan D Price
Jul 6, 2013·Science·Ryan ListerJoseph R Ecker
Sep 14, 2013·Brain : a Journal of Neurology·Jose V Sanchez-MutManel Esteller
Oct 1, 2013·Journal of Alzheimer's Disease : JAD·Noor TaherGary D Isaacs
Nov 5, 2013·Neuron·J David Sweatt
Jan 28, 2014·Nature Neuroscience·Bess FrostMel B Feany
Aug 19, 2014·Nature Neuroscience·Philip L De JagerDavid A Bennett
Aug 19, 2014·Nature Neuroscience·Katie LunnonJonathan Mill

❮ Previous
Next ❯

Citations

Apr 2, 2016·Briefings in Functional Genomics·Fu-Hui XiaoYong-Han He
Apr 22, 2016·Nucleic Acids Research·Jüri ReimandJaak Vilo
Mar 2, 2013·PloS One·Ramon M RodriguezCarlos Lopez-Larrea
Sep 17, 2013·PLoS Genetics·Irene Hernando-HerraezTomas Marques-Bonet
Oct 17, 2012·PLoS Genetics·Devin Coleman-Derr, Daniel Zilberman
Mar 2, 2013·PloS One·Ilya S Belalov, Alexander N Lukashev
Feb 6, 2014·PloS One·Fang LiangRujiao Li
Aug 22, 2014·PLoS Computational Biology·Ken Daigoro YokoyamaJian Ma
Jan 10, 2014·PloS One·Vincent CousthamNicolas Bouché
Jul 16, 2014·PloS One·Nongluk PlongthongkumKun Zhang
Apr 18, 2013·PLoS Computational Biology·Emily V ChambersColin A Semple
Aug 23, 2011·PloS One·Suzanne E PetersonJerold Chun
Dec 5, 2012·PLoS Pathogens·Elena Gómez-DíazAna Rivero
May 21, 2014·PloS One·Andrea ManconiLuciano Milanesi
Jun 12, 2013·PLoS Genetics·Shengnan JinChunming Ding
Sep 13, 2012·PloS One·Laurynas DaugelaOsman El-Maarri

❮ Previous
Next ❯

Methods Mentioned

BETA
WGBS
PCR
produced

Software Mentioned

gProfiler
SAMtools
Tabix
Bismark
CCAT peak caller
bedtools
R
Circos
PyroMark assay design
CCAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.