Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.

The Journal of Biological Chemistry
Jesus EspadaManel Esteller

Abstract

DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is thought to be the enzyme primarily responsible for maintenance of the global methylation status of genomic DNA. However, loss of DNMT1 in human cancer cells affects only the methylation status of a limited number of pericentromeric sequences. Here we show that human cancer cells lacking DNMT1 display at least two important differences with respect to wild type cells: a profound disorganization of nuclear architecture, and an altered pattern of histone H3 modification that results in an increase in the acetylation and a decrease in the dimethylation and trimethylation of lysine 9. Additionally, this phenotype is associated with a loss of interaction of histone deacetylases (HDACs) and HP1 (heterochromatin protein 1) with histone H3 and pericentromeric repetitive sequences (satellite 2). Our data indicate that DNMT1 activity, via maintenance of the appropriate histone H3 modifications, contributes to the preservation of the correct organization of large heterochromatic regions.

References

Mar 1, 1994·Nature Genetics·S H CrossA P Bird
Mar 1, 1997·Human Molecular Genetics·G J Brock, A Bird
Feb 9, 1999·Human Molecular Genetics·T H HuangD E Laux
May 18, 1999·Experimental Cell Research·M HabibA Niveleau
Dec 30, 1999·Nature Genetics·F FuksT Kouzarides
Jan 19, 2000·Nature·B D Strahl, C D Allis
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B M Turner
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Mar 20, 2001·Nature Reviews. Molecular Cell Biology·C FrancastelM Groudine
Apr 3, 2001·Nature Reviews. Genetics·T Cremer, C Cremer
Aug 11, 2001·Science·T Jenuwein, C D Allis
Dec 12, 2001·Nature Genetics·Antoine H F M PetersThomas Jenuwein
Jan 5, 2002·Molecular and Cellular Biology·Gangning LiangPeter A Jones
Apr 5, 2002·Nature·Ina RheeBert Vogelstein
Jun 29, 2002·Nature Genetics·Siavash K KurdistaniMichael Grunstein
Aug 2, 2002·Trends in Biochemical Sciences·Robert SchneiderTony Kouzarides
Aug 22, 2002·Nature Reviews. Cancer·Shi Huang
Dec 24, 2002·Nature Genetics·Marie-France RobertA Robert MacLeod
Apr 15, 2003·Nature Genetics·Shutao CaiTerumi Kohwi-Shigematsu
Apr 25, 2003·Nucleic Acids Research·François FuksTony Kouzarides
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad TariqJerzy Paszkowski
Oct 11, 2003·Molecular Cell·Didier TroucheStefan Dimitrov
Nov 25, 2003·The EMBO Journal·Esteban BallestarManel Esteller
Dec 24, 2003·Molecular Cell·Antoine H F M PetersThomas Jenuwein

❮ Previous
Next ❯

Citations

Jan 16, 2007·Cellular and Molecular Life Sciences : CMLS·J Espada, M Esteller
Sep 10, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sivan Vadakkadath MeethalBermans J Iskandar
Sep 9, 2006·Histochemistry and Cell Biology·Olufunmilade A OmisanjoKlaus Steger
Jan 26, 2010·Cancer Metastasis Reviews·Gerwin HellerSabine Zöchbauer-Müller
Aug 5, 2009·Clinical Reviews in Allergy & Immunology·Esteban Ballestar
Mar 7, 2007·Nature Reviews. Genetics·Manel Esteller
Mar 20, 2010·Nature Reviews. Genetics·Raphaël Margueron, Danny Reinberg
Aug 6, 2008·DNA and Cell Biology·Jill Sergesketter ButlerDavid G Skalnik
Oct 29, 2004·Nucleic Acids Research·Myungjin KimPeter W Laird
Dec 6, 2008·Nucleic Acids Research·Jong Kyong KimSriharsa Pradhan
Aug 19, 2011·Nucleic Acids Research·Jesús EspadaManel Esteller
May 4, 2010·Anti-cancer Drugs·Katarina Sebova, Ivana Fridrichova
Nov 7, 2006·Genes & Development·Pierre-Olivier EstèveSriharsa Pradhan
May 2, 2007·Genes & Development·Andrea SmallwoodMichael Carey
Apr 19, 2011·Genes & Development·Yoichi Shinkai, Makoto Tachibana
Jul 22, 2010·Development, Growth & Differentiation·Kentaro Mochizuki, Yasuhisa Matsui
Jun 15, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Rayleen V BowmanKwun M Fong
Sep 19, 2006·Molecular and Cellular Biology·Kunal RaiDavid A Jones
Jun 17, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Esteban Ballestar, Manel Esteller
Jun 17, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Michèle J Hoffmann, Wolfgang A Schulz
Nov 6, 2009·Annual Review of Genetics·Eric I Campos, Danny Reinberg
Jul 5, 2008·Annual Review of Nutrition·Barbara Delage, Roderick H Dashwood
Nov 26, 2010·The Journal of Clinical Investigation·Patrick G GallagherDavid M Bodine
Oct 26, 2010·Endocrine Reviews·Z HochbergK Albertsson-Wikland
Aug 2, 2008·PLoS Genetics·Anders M LindrothPaul D Soloway
Feb 1, 2010·Epigenomics·Neil P Blackledge, Robert J Klose
Jul 24, 2014·CNS Oncology·Jonas EckerTill Milde
Oct 25, 2012·International Journal of Nephrology·Jacob Hofman-BangEwa Lewin
Dec 10, 2009·The Journal of Reproduction and Development·Hui Wen LimKunio Shiota
Mar 8, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael J Morris, Lisa M Monteggia
Dec 26, 2015·International Journal of Molecular Sciences·Agnieszka Kaufman-SzymczykKrystyna Fabianowska-Majewska
Jan 5, 2011·Protein & Cell·Mo Xu, Bing Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.