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Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

The Journal of Biological Chemistry

Jun 29, 2004

Jesus EspadaManel Esteller

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Abstract

DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is thought to be the enzyme primarily responsible for maintenance of the global methylation status of genomic DNA. However, loss of DNMT1 in human cancer cells affects only the methylation status of a limi...read more

Mentioned in this Paper

Precipitin Tests
Repetitive Region
Chromosomal Proteins, Non-Histone
Micrococcal Nuclease
Protein Methylation
DNMT1 wt Allele
Murine
Electrophoresis, Capillary
DNA Methylation
Immunofluorescence Microscopy
100
1
Paper Details
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Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

The Journal of Biological Chemistry

Jun 29, 2004

Jesus EspadaManel Esteller

PMID: 15220328

DOI: 10.1074/jbc.m404842200

Abstract

DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is thought to be the enzyme primarily responsible for maintenance of the global methylation status of genomic DNA. However, loss of DNMT1 in human cancer cells affects only the methylation status of a limi...read more

Mentioned in this Paper

Precipitin Tests
Repetitive Region
Chromosomal Proteins, Non-Histone
Micrococcal Nuclease
Protein Methylation
DNMT1 wt Allele
Murine
Electrophoresis, Capillary
DNA Methylation
Immunofluorescence Microscopy
100
1

Feeds With Similar Papers

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Heterochromatin Function

Heterochromatin is condensed chromatin that was previously believed to be inaccessible for transcription, although this has been disproven. Heterochromatin plays a role in gene expression. Find the latest research on heterochromatin here.

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Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

Cancer CellFebruary 1, 2003
Kurtis E BachmanBert Vogelstein
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  • Citations91
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  • Citations91
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