Human dorsomedial parieto-motor circuit specifies grasp during the planning of goal-directed hand actions

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Michael VesiaRobert Chen

Abstract

According to one influential view, two specialized parieto-frontal circuits control prehension: a dorsomedial stream for hand transport during reaching and a dorsolateral stream for preshaping the fingers during grasping. However, recent evidence argues that an area within the dorsomedial stream-macaque area V6A and, its putative human homolog, superior parietal occipital cortex (SPOC) - encodes both hand transport and grip formation. We tested whether planning varied hand actions modulates functional connectivity between left SPOC and ipsilateral primary motor cortex (M1) using a dual-site, paired-pulse transcranial magnetic stimulation paradigm with two coils (dsTMS). Participants performed three different hand actions to a target object comprising a small cylinder atop a larger cylinder. These actions were: reaching-to-grasp the top (GT) using a precision grip, reaching-to-grasp the bottom (GB) using a whole-hand grip, or reaching-to-touch (Touch) the side of the target object without forming a grip. Motor-evoked potentials (MEPs) from TMS to M1, with or without preceding TMS to SPOC, were recorded from first dorsal interosseous (FDI) and abductor digiti minimi (ADM) hand muscles in two experiments that varied timing paramet...Continue Reading

Citations

Jan 22, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gerard Derosiere, Julie Duque
Apr 25, 2018·Cerebral Cortex·Henrietta HowellsMarco Catani
Nov 13, 2019·Brain Structure & Function·Michela GamberiniClaudio Galletti
May 22, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Fabrice F HannanuAssia Jaillard
Feb 19, 2021·Frontiers in Aging Neuroscience·Elana R GoldenkoffMichael Vesia
Jul 12, 2021·Brain Structure & Function·Giulia Malfatti, Luca Turella
Sep 18, 2021·Scientific Reports·Simone RossiDomenico Prattichizzo

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