Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.

F&S Science
Sandeep K RajputRebecca L Krisher


To study messenger ribonucleic acid (mRNA) and protein expressions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry receptors (angiotensin 1-converting enzyme 2 [ACE2] and CD147) and proteases (transmembrane serine protease 2 [TMPRSS2] and cathepsin L [CTSL]) in human oocytes, embryos, and cumulus (CCs) and granulosa cells (GCs). Research study. Clinical in vitro fertilization (IVF) treatment center. Patients undergoing IVF were treated at the Colorado Center for Reproductive Medicine. Oocytes (germinal vesicle and metaphase II [MII]) and embryos (1-cell [1C] and blastocyst [BL]) were donated for research at the disposition by the patients undergoing IVF. Follicular cells (CC and GC) were collected from women undergoing egg retrieval after ovarian stimulation without an ovulatory trigger for in vitro maturation/IVF treatment cycles. Presence or absence of ACE2, CD147, TMPRSS2, and CTSL mRNAs detected using quantitative reverse transcription polymerase chain reaction and proteins detected using capillary Western blotting in human oocytes, embryos, and ovarian follicular cells. The quantitative reverse transcription polymerase chain reaction analysis revealed high abundance of ACE2 gene transcripts in germina...Continue Reading


Apr 20, 2004·Advances in Anatomic Pathology·Anthony S-Y Leong
Aug 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Graham SimmonsPaul Bates
Apr 14, 2009·Molecular Reproduction and Development·Alexei V Evsikov, Caralina Marín de Evsikova
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
May 28, 2010·Journal of Cellular Biochemistry·Marcia PuchiVioleta Morin
Mar 14, 2012·Nature Reviews. Genetics·Christine Vogel, Edward M Marcotte
Oct 25, 2013·International Journal of Molecular Sciences·Pei-Pei PanFan Jin
Apr 18, 2014·International Journal of Molecular Sciences·Yang BaiZhi-Nan Chen
Feb 23, 2020·The Lancet Infectious Diseases·Ensheng DongLauren Gardner
Jan 1, 2006·International Journal of Peptide Research and Therapeutics·Rebecca A LewA Ian Smith
Apr 17, 2020·Biology of Reproduction·Ci SongYun Liu
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network
May 5, 2020·Molecular Human Reproduction·Yan JingChen Fei
May 15, 2020·Reproductive Biology and Endocrinology : RB&E·Carlo AlviggiUNKNOWN POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group
May 18, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Christian A DevauxDidier Raoult
May 20, 2020·Biology of Reproduction·Saguna VermaHooman Sadri-Ardekani
May 29, 2020·Journal of Assisted Reproduction and Genetics·Amir Arav
May 30, 2020·Reproductive Biomedicine Online·Rong LiJie Qiao
May 30, 2020·Reproductive Biomedicine Online·George AnifandisIoannis E Messinis
Jun 3, 2020·Fertility and Sterility·James SegarsUNKNOWN American Society for Reproductive Medicine Coronavirus/COVID-19 Task Force
Jul 6, 2020·Reproductive Biomedicine Online·Cristina HickmanHong Ye
Sep 19, 2020·Cell Reports·Manvendra SinghCédric Feschotte

❮ Previous
Next ❯


Jun 2, 2021·Systems Biology in Reproductive Medicine·George AnifandisIoannis E Messinis

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned

Simple Western Compass
Ensemble genome browser

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.