Abstract
Successful implantation and placentation depend on the interaction between the endometrium and the embryo. Angiogenesis is crucial at this time. In this article we investigate the direct influence of the human embryo on in vitro endometrial angiogenesis. In vitro study. Human endometrial microvascular endothelial cells (hEMVEC) grown on an in vitro angiogenesis model. Conditioned media (CM) of human embryos were used to stimulate in vitro angiogenesis. In vitro angiogenesis of hEMVEC. Conditioned media of human embryos, containing significant amounts of vascular endothelial growth factor (VEGF)-A, as determined by enzyme-linked immunosorbent assay (ELISA), caused an increase in hEMVEC tube formation. This effect was prevented by soluble VEGF receptor 1, which quenches VEGF-A activity. Recombinant EGF alone and leukemia inhibitory factor in combination with VEGF-A stimulated hEMVEC tube formation. None of the other tested recombinant mediators, which have been described as produced by the early embryo/trophoblast (interleukin (IL) 10, transforming growth factor (TGF) beta, placental growth factor, hCG, colony-stimulating factor 1, interferon-gamma, insulin-like growth factor I and II, IL-6, platelet-derived growth factor, and TG...Continue Reading
Citations
Nov 22, 2011·Archives of Gynecology and Obstetrics·Ensieh Shahrokhe TehraninejadHaleh Rahmanpour Zanjani
Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
Oct 30, 2012·Journal of Assisted Reproduction and Genetics·Radia BoudjenahFrançois Vialard
Feb 19, 2016·The Journal of Obstetrics and Gynaecology Research·Peng ChenYan-Ming Liang
Dec 18, 2015·Reproductive Biomedicine Online·Yong Wook JungNam Keun Kim
May 22, 2008·Reproductive Biomedicine Online·Cammi GoodmanC B Coulam
Apr 13, 2010·Reproductive Biomedicine Online·Els GroeneveldCornelis B Lambalk
Jun 2, 2009·Acta histochemica·Ramazan DemirBerthold Huppertz
Oct 22, 2008·Fertility and Sterility·Sakae GotoMasahide Shiotani
Oct 3, 2008·Fertility and Sterility·Cammi GoodmanC B Coulam
Mar 8, 2008·Fertility and Sterility·Kitty KapiteijnFrans M Helmerhorst
Jun 15, 2011·Reproductive Biomedicine Online·Sarah NordqvistHelena Akerud
Dec 15, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Margreet Plaisier
Mar 27, 2007·Placenta·F HerrM Zygmunt
Mar 27, 2007·Fertility and Sterility·Gregory W ThomasDavid Bar-Or
Oct 16, 2008·Human Reproduction·M PlaisierF M Helmerhorst
Apr 25, 2017·Journal of Cellular Biochemistry·Mostafa Peyvandi KarizbodaghHamed Mirzaei
Jul 20, 2010·Reproductive Sciences·Sarah NordqvistHelena Akerud
Dec 26, 2015·Reproductive Sciences·Jihyun KimJin Hyun Jun
Aug 22, 2008·Immunological Investigations·Caroline DunkRebecca Lee Jones
Feb 13, 2018·Experimental and Therapeutic Medicine·Sung Han ShimNam Keun Kim
Aug 17, 2020·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisDennis Vaidakis
Aug 23, 2020·Animals : an Open Access Journal From MDPI·Kihae RaByeong Chun Lee
Nov 25, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soheila SalmasiBahman Rashidi
Feb 14, 2021·Biomolecules·Xi GuoXiaoyan Chen
Dec 6, 2020·Obstetrics and Gynecology·Jessica R ZoltonEnrique F Schisterman
Mar 6, 2018·Reproductive Toxicology·Uros MidicKeith E Latham
Apr 24, 2021·Archives of Gynecology and Obstetrics·Hong ZengSong Quan