Human embryonal carcinoma stem cells: models of embryonic development in humans

Stem Cells and Development
S A PrzyborskiG M Horrocks

Abstract

There are few reliable experimental systems available to study the molecular mechanisms that govern human embryonic development. Embryonal carcinoma (EC) cells are pluripotent stem cells derived from teratocarcinomas and are considered the malignant counterparts of human embryonic stem (ES) cells. Several of the existing human EC stem cell lines provide robust and simple culture systems to study certain aspects of cellular differentiation in a manner pertinent to human embryogenesis. Here we review the strategies used to derive and characterize the established and recognized human EC stem cell line TERA2.cl.SP12. Furthermore, we demonstrate the value of human EC stem cells as a model of early development and focus on cell fate determination in the embryonic ectoderm.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G S EisenbarthM Nirenberg
Oct 1, 1989·Differentiation; Research in Biological Diversity·M F PeraJ M Parrington
Dec 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·H Grunz, L Tacke
Jul 1, 1989·Developmental Biology·S M Sato, T D Sargent
Aug 1, 1989·Developmental Biology·S F Godsave, J M Slack
Aug 15, 1980·Science·G R Martin
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·P W Andrews
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P YounkinD Pleasure
Apr 1, 1995·Developmental Biology·G BainD I Gottlieb
Jun 11, 1996·International Journal of Cancer. Journal International Du Cancer·P W AndrewsP Stern
Sep 1, 1997·Developmental Biology·A SuzukiA Hemmati-Brivanlou
Nov 6, 1998·Science·J A ThomsonJ M Jones
Apr 23, 1999·The Journal of Comparative Neurology·R S HartleyC M Tang
Dec 28, 1999·Reproduction, Fertility, and Development·M F Pera, D Herszfeld
Apr 5, 2000·Nature Biotechnology·B E ReubinoffA Bongso
Oct 13, 2000·The European Journal of Neuroscience·S A PrzyborskiP W Andrews
May 30, 2002·Journal of Anatomy·Jonathan S DraperPeter W Andrews
Apr 25, 2003·Biochemical and Biophysical Research Communications·Grace M HorrocksStefan Przyborski

❮ Previous
Next ❯

Citations

Mar 5, 2009·Journal of Biomedical Optics·Amirreza ArefJeremy J Ramsden
Jun 18, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Maryam ShahhoseiniHossein Baharvand
Sep 24, 2009·BMC Biotechnology·Margarida SerraPaula M Alves
Apr 20, 2007·Journal of Negative Results in Biomedicine·Pedro D Simões, Teresa Ramos
May 1, 2007·Regenerative Medicine·Rajarshi PalAparna Khanna
Jun 20, 2014·Biochimica Et Biophysica Acta·Richard L GieseckNicholas R F Hannan
Feb 11, 2016·Stem Cell Reports·Cheryl Q E LeeAshley Moffett
Apr 25, 2006·Cancer Science·Hitoshi KojiShinobu Gamou
Feb 5, 2013·Journal of Applied Toxicology : JAT·Debasish HalderYoung Gyu Chai
Mar 19, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Incoronata LaurenzaAnna Bal-Price
Feb 10, 2007·Developmental Biology·Siam OottamasathienRobert J Matusik
Feb 1, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·William S CaoRobert F Halliwell
May 2, 2006·Stem Cells and Development·M J CookeS A Przyborski
Jan 27, 2007·Stem Cells and Development·Stan Filip
Sep 18, 2007·Journal of Neuroscience Research·Margarida SerraPaula M Alves
Jan 18, 2020·Stem Cells International·Nuwanka K AbeysingheAnuka S Mendis
Dec 5, 2018·Brain and Neuroscience Advances·Kirsty Goncalves, Stefan Przyborski
Sep 19, 2006·Stem Cells and Development·Geeta Ravindran, Harinarayana S Rao
Jul 1, 2017·BMC Complementary and Alternative Medicine·Faisal S AlagrafiMohammad A Wadaan
Aug 3, 2020·Andrology·Kasit ChatsirisupachaiArthit Chairoungdua
Dec 17, 2008·Organic & Biomolecular Chemistry·Victoria B ChristieAndrew Whiting
Jan 5, 2014·Stem Cells and Development·Ritu KushwahaR S K Chaganti
Mar 1, 2017·Molecular Neurobiology·Hesham HaffezAndrew Whiting

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Fate Specification

Cell fate specification is determined by complex signal transduction pathways including Notch and the Sonic hedgehog signaling pathway. Here is the latest research on regulation of cell fate determination.