Human Embryonic Stem Cells-Derived Mesenchymal Stem Cells Reduce the Symptom of Psoriasis in Imiquimod-Induced Skin Model

Tissue Engineering and Regenerative Medicine
Chang-Hyun KimEun Ju Lee

Abstract

Mesenchymal stem cells (MSCs) can be used for a wide range of therapeutic applications because of not only their differentiation potential but also their ability to secrete bioactive factors. Recently, several studies have suggested the use of human embryonic stem cell-derived MSCs (hE-MSCs) as an alternative for regenerative cellular therapy due to mass production of MSCs from a single donor. We generated hE-MSCs from embryonic stem cell lines, SNUhES3, and analyzed immune properties of these cells. Also, we evaluated the in-vivo therapeutic potential of hE-MSCs in immune-mediated inflammatory skin disease. The cell showed the suppression of immunity associated with allogenic peripheral blood mononuclear cells in mixed lymphocyte response assay. We also detected that cytokines and growth factor related to the immune response were secreted from these cells. To assessed the in-vivo therapeutic potential of hE-MSCs in immune-mediated inflammatory skin disease, we used imiquimod (IMQ)-induced skin psoriasis mouse model. The score of clinical skin was significantly reduced in the hE-MSCs treated group compared with control IMQ group. In histological analysis, the IMQ-induced epidermal thickness was significantly decreased by hE-MSC...Continue Reading

References

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Citations

May 10, 2020·Clinical and Experimental Dermatology·A PaganelliC Magnoni
Apr 21, 2020·Current Pharmaceutical Design·Guifang ZhaoWenliang Li
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan XingJianhao Lin
Mar 26, 2021·Tissue Engineering and Regenerative Medicine·Ji Suk ChoiSeong Keun Kwon
Dec 10, 2021·Journal of Wound Care·Kyu Sang Cho, Jang Hyun Lee

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