Human endogenous retrovirus group E and its involvement in diseases

Viruses
Christelle Le DantecYves Renaudineau

Abstract

Human endogenous retrovirus group E (HERV-E) elements are stably integrated into the human genome, transmitted vertically in a Mendelian manner, and are endowed with transcriptional activity as alternative promoters or enhancers. Such effects are under the control of the proviral long terminal repeats (LTR) that are organized into three HERV-E phylogenetic subgroups, namely LTR2, LTR2B, and LTR2C. Moreover, HERV-E expression is tissue-specific, and silenced by epigenetic constraints that may be disrupted in cancer, autoimmunity, and human placentation. Interest in HERV-E with regard to these conditions has been stimulated further by concerns regarding the capacity of HERV-E elements to modify the expression of neighboring genes and/or to produce retroviral proteins, including immunosuppressive env peptides, which in turn may induce (auto)-antibody (Ab) production. Finally, better understanding of HERV-E elements may have clinical applications for prevention, diagnosis, prognosis, and therapy.

References

Jun 1, 1985·Journal of Virology·R RepaskeM A Martin
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M A MartinA S Khan
Jan 1, 1996·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M A TurbevilleP E Steele
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Nov 2, 2002·Molecular Biology and Evolution·Josette-Renée LandryDixie L Mager
Jun 14, 2003·Journal of Virology·Josette-Renée Landry, Dixie L Mager
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert BelshawMichael Tristem
Sep 2, 2004·Cold Spring Harbor Symposia on Quantitative Biology·E Birney, UNKNOWN Ensembl Team
Aug 19, 2005·Genes and Immunity·Y RenaudineauP Youinou
Aug 20, 2005·Trends in Microbiology·Aris KatzourakisOliver G Pybus
Dec 31, 2005·Archives of Virology·J-M Yi, H-S Kim
Sep 29, 2006·Genome Biology·Louie N van de LagemaatDixie L Mager
Jun 22, 2007·Journal of Virology·Robert BelshawMichael Tristem
Jul 10, 2007·Nucleic Acids Research·Daphne ReissDixie L Mager
Dec 14, 2007·Journal of Virology·Oliver FrankWolfgang Seifarth
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soizic GaraudYves Renaudineau
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soizic GaraudYves Renaudineau
Sep 18, 2009·Annals of the New York Academy of Sciences·Soizic GaraudYves Renaudineau
Jan 8, 2010·Journal of Autoimmunity·Wesley H BrooksYves Renaudineau
Jan 22, 2011·Virology·Helen M Rowe, Didier Trono
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soizic GaraudPierre Youinou
Apr 5, 2011·The Keio Journal of Medicine·Yves Renaudineau, Pierre Youinou
Jun 2, 2011·Advances in Experimental Medicine and Biology·Soizic GaraudYves Renaudineau
Jan 1, 2010·Arthritis·Ruby Alonso-RamirezYves Renaudineau
Jan 3, 2012·Current Pharmaceutical Biotechnology·Christelle Le DantecYves Renaudineau
Feb 22, 2012·Autoimmunity Reviews·Rizgar A MageedPierre Youinou
Jun 23, 2012·Nature·Todd S MacfarlanSamuel L Pfaff

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Citations

Jan 23, 2016·Frontiers in Molecular Neuroscience·Antonio Benítez-Burraco, Juan Uriagereka
Jun 28, 2016·Clinical Reviews in Allergy & Immunology·Laurent SimoninYves Renaudineau
Sep 2, 2016·Frontiers in Microbiology·Marina I ArleevskayaAnatoly P Tsibulkin
Feb 28, 2017·Médecine sciences : M/S·Julie Medina, Hervé Perron
Mar 24, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Rossella TalottaMagdalena Janina Laska
Aug 12, 2015·Retrovirology·Amnon Hizi, Eytan Herzig
Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Malgorzata TrelaPaul B Rylance
May 7, 2019·Frontiers in Microbiology·Marina I ArleevskayaYves Renaudineau

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Methods Mentioned

BETA
ELISA

Software Mentioned

Ortheus
ensembl
- Pecan
Pecan
MEGA
- Ortheus ( EPO
human BLASTN
BioEdit
Enredo
ClustalW

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