Human endogenous retrovirus (HERV)-K transcripts in germ cell and trophoblastic tumours

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
H HerbstNikolaus Mueller-Lantzsch

Abstract

Prompted by the observation of retroviral particle formation in teratocarcinoma cell lines and the consistent finding of antibodies against Gag and Env proteins encoded by human endogenous retrovirus (HERV)-K genomes in the sera of patients with classical seminoma, we studied ovarian and testicular germ cell tumours, their precursor lesions, dysgenetic gonads, and trophoblast lesions for expression of HERV-K sequences by in situ hybridization using radioactive and non-radioactive probes. HERV-K transcripts were detected in all testicular and ovarian germ cell tumours with the exception of teratomas and spermatocytic seminomas. HERV-K expression was also common to testicular carcinoma in situ as well as gonocytes of dysgenetic gonads. Among gestational trophoblastic lesions, HERV-K expression was regularly found in choriocarcinomas, but not in molar lesions. The patterns of HERV-K expression suggest a common molecular pathogenesis of most germ cell tumour entities and malignant gestational trophoblastic disease. They furthermore support the concept of carcinoma in situ as a precursor lesion common to most testicular germ cell neoplasms. The detection of HERV-K gene products in body fluids and tissues may aid diagnosis and monito...Continue Reading

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Citations

Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
Aug 12, 2005·Cytogenetic and Genome Research·S PrudhommeF Mallet
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Aug 3, 2002·Oncogene·Melanie Ehrlich
Mar 12, 2003·Oncogene·Feng Wang-JohanningGary L Johanning
Mar 30, 2001·The Journal of Biological Chemistry·R KuheljB D Korant
Nov 11, 2020·Nature Communications·Sunil Kumar SainiSine Reker Hadrup
May 19, 2005·Cancer Research·Kristina BüscherJoachim Denner

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