Human endometrial cytodifferentiation by histone deacetylase inhibitors.

Human Cell
Hiroshi UchidaYasunori Yoshimura

Abstract

Abstract Human uterine endometrium repeats proliferation, differentiation (decidualization) and tissue breakdown during the menstrual period. Appropriate secretion of ovarian steroid hormones regulates these sequential endometrial remodeling cycles. While progesterone replacement therapy is adopted for endometrial dysfunction of differentiation, including recurrent impairment of implantation, no obvious effective results are obtained. Histone reversible acetylation, regulated by histone acetyltransferases and histone deacetylases plays a pivotal role in gene transcription. Although, in cells cultured with histone deacetylase inhibitors (HDACI), the expression of only about 2% of expressed genes is changed twofold or more compared with untreated control cells. Numerous previous works have demonstrated that HDACI affect cell proliferation/apoptosis in a variety of types of cells. To date, several HDACI are in phase I or phase II clinical trials as anticancer drugs. However, no reports have been found that HDACI is useful for transdifferentiation in human endometrium. Recently, we reported that HDACI could induce the expression of differentiation marker proteins, morphological change and functional cytodifferentiation in both huma...Continue Reading

References

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May 3, 2005·Reproductive Medicine and Biology·Hiroshi UchidaYasunori Yoshimura

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Citations

Apr 28, 2012·Gynecologic and Obstetric Investigation·Xishi LiuSun-Wei Guo
Nov 10, 2011·Molecular and Cellular Endocrinology·Sun-Wei Guo
May 7, 2020·Journal of Clinical Medicine·Anna ZubrzyckaMaria Zubrzycka
Nov 14, 2019·International Journal of Molecular Sciences·Antonio Simone LaganàDan C Martin
May 27, 2021·Clinical Epigenetics·Alejandra Monserrat Retis-ResendizEdgar Ricardo Vázquez-Martínez

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