PMID: 8955505Nov 1, 1996Paper

Human endometrial expression of granulocyte colony-stimulating factor (G-CSF) and its receptor, stimulation of endometrial G-CSF production by interleukin-1 beta, and G-CSF inhibition of choriocarcinoma cell proliferation

American Journal of Reproductive Immunology : AJRI
D T Vandermolen, Y Gu

Abstract

To investigate the expression, regulation thereof, and actions of human endometrial granulocyte colony-stimulating factor (G-CSF). Endometrial expression of messenger ribonucleic acids for G-CSF and its receptor were studied using reverse transcriptase-polymerase chain reaction. In tissue culture, endometrial G-CSF protein production, baseline and in response to interleukin-1 beta, was determined by enzyme-linked immunosorbant assay of the conditioned media. G-CSF effects on proliferation of three choriocarcinoma cell lines were determined. In vivo, human endometrium expressed messenger ribonucleic acids for G-CSF and its receptor throughout the menstrual cycle, and endometrium expressed G-CSF protein in vitro. Interleukin-1 beta stimulated endometrial G-CSF protein production in time and dose dependent manners. G-CSF inhibited proliferation of two choriocarcinoma cell lines. These results suggest that 1) G-CSF may have physiologic roles in the endometrium throughout the menstrual cycle; 2) endometrial G-CSF protein production is stimulated by interleukin-1 beta; and 3) that G-CSF may, in part, mediate local actions of interleukin-1 beta and modulate trophoblast proliferation.

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·D J DudleyM D Mitchell
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R FukunagaS Nagata
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H UzumakiY Umezawa
Jan 1, 1989·Annals of the New York Academy of Sciences·P J QuesenberryD H Deacon
Jun 5, 1987·Science·S C Clark, R Kamen
Jan 1, 1993·Fertility and Sterility·J H McBean, J R Brumsted

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Citations

Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaneh Abdolmohammadi-VahidMehdi Yousefi
Nov 28, 2002·Biological Chemistry·Lars Hareng, Thomas Hartung
Dec 31, 2014·Endocrine Reviews·George A ThouasDavid K Gardner
Nov 28, 2012·American Journal of Reproductive Immunology : AJRI·Michelle Van SinderenEvdokia Dimitriadis
Aug 30, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ruochun LianSu Liu
May 20, 2005·Reproductive Biomedicine Online·Serena EmilianiYvon Englert

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