PMID: 9161640Apr 1, 1997Paper

Human endometrial leukemia inhibitor factor (LIF) secretion and its relationship to sonographic endometrial appearance

American Journal of Reproductive Immunology : AJRI
E Hambartsoumian

Abstract

LIF is believed to be involved in human reproduction. Because little is known about the function of this cytokine in proliferative phase of cycle and because LIF is found to regulate the cellular growth we evaluated the possible relationship between endometrial LIF secretion and endometrial growth. The present is prospective, blinded study with clinical and immunobiochemical correlation between endometrial LIF concentration and endometrial ultrasound pattern. Twenty-four patients who were candidates for IVF and oocyte donation are included in this study. At day 10 of their cycle the endometrial biopsy was performed, followed by vaginal sonographic measurements of endometrial thickness and pattern. Endometrial LIF concentration was measured by ELISA in supernatants taken from cultured explants. Endometrial LIF production significantly negatively correlated with endometrial thicknesses (P < 0.05). There was a 4-fold elevation in LIF production when the endometrial thickness was below 5 mm. Strong correlation was found also between endometrial LIF production and sonographic endometrial pattern (P < 0.05). The most significant amount of LIF was found in nonfavorable endometria. In the proliferative phase of cycle there is a dynamic...Continue Reading

References

Mar 1, 1991·International Journal of Cell Cloning·D Metcalf
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H BhattC L Stewart
May 1, 1991·Journal of Cellular Biochemistry·D J Hilton, N M Gough
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Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·E B CullinanC L Stewart

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Citations

Nov 24, 2007·Seminars in Cell & Developmental Biology·L AghajanovaL C Giudice
Jul 28, 2004·American Journal of Reproductive Immunology : AJRI·Zdzisława Kondera-AnaszAleksandra Mielczarek-Palacz
Apr 4, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E Hambartsoumian
Jun 17, 2000·Endocrine Reviews·C J Auernhammer, S Melmed
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·L M Senturk, A Arici

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