PMID: 6538515Mar 12, 1984Paper

Human endothelial cells contain one type of plasminogen activator

FEBS Letters
P KristensenK Danø

Abstract

At least two types of animal plasminogen activating enzymes exist, differing in amino acid sequence, molecular mass and immunological reactivity: the urokinase-type and the tissue-type plasminogen activators. By affinity chromatography with monoclonal antibodies, we have purified the human activators of both types to homogeneity. Using immunocytochemistry with rabbit antibodies raised against these preparations, we now demonstrate that the plasminogen activator present in endothelium of veins and other blood vessels is of the tissue-type. No urokinase-type plasminogen activator immunoreactivity was detected in endothelial cells in the intact organism. These findings support the assumption that mobilization of plasmin for different purposes may involve different types of plasminogen activators, and that the plasminogen activator involved in thrombolysis is of the tissue-type.

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Citations

Jan 1, 1990·Histochemistry·P KristensenK Danø
Jan 1, 1989·Histochemistry·J EriksenK Danø
Jan 1, 1986·Histochemistry·P KristensenK Danø
Aug 1, 1994·The International Journal of Biochemistry·V N NikandrovN V Demidchik
Jan 2, 1990·Molecular and Cellular Endocrinology·P A AndreasenS N Stacey
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Jan 1, 1997·Progress in Cardiovascular Diseases·H R Lijnen, D Collen
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Feb 1, 1995·The Journal of Dairy Research·J H WhiteI Politis
Apr 15, 1989·Thrombosis Research·H ShimadaY Takada

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