Human epidermal growth factor for the stratification of synovial lining layer and neovascularisation in rheumatoid arthritis.

Annals of the Rheumatic Diseases
S ShiozawaS Imura

Abstract

Immunohistochemical study showed selective localisation of human epidermal growth factor (hEGF) to the synovial lining layer. Although the synovial lining layer of the rheumatoid, osteoarthritic, and traumatic joints was hEGF positive, hEGF staining was especially dense at the rheumatoid synovial lining layer; the staining increasing linearly according to the degree of stratification of the lining layer (r = 1). Human epidermal growth factor was ultrastructurally localised to cytoplasm, especially to rough endoplasmic reticulum, of the synovial lining fibroblast-like (type B) cell. Only the cell surface of macrophage-like (type A) cells was hEGF positive. When different histological variables were compared with each other a positive correlation was found between hEGF staining of the synovial lining layer and the degree of neovascularisation of rheumatoid synovium (r = 0.72). Although some lymphocytes were weakly hEGF positive, neovascularisation did not correlate with the extent of lymphocyte infiltration or of hEGF staining of lymphocytes. Lymphocyte infiltration or hEGF staining of lymphocytes did not correlate with hEGF staining of the synovial lining layer, whereas the lymphocyte infiltration correlated positively with the ...Continue Reading

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Citations

Jan 1, 1994·Immunologic Research·S H ZwillichW V Williams
Nov 28, 2012·Clinical Rheumatology·Feng-Lai YuanRui-Sheng Xu
Jul 1, 1992·Annals of the Rheumatic Diseases·P R Colville-Nash, D L Scott
Dec 1, 1993·Annals of the Rheumatic Diseases·M N FarahatG S Panayi
Sep 2, 2005·Scandinavian Journal of Rheumatology·A L HallbeckA Wasteson
Jan 1, 1994·Scandinavian Journal of Rheumatology. Supplement·G W Duff
Mar 14, 2003·Rheumatology International·Ihsan ErtenliMeral Calgüneri
Jan 7, 2010·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Timothy SullivanJohn F Deeken
Apr 1, 1992·Arthritis and Rheumatism·S ShiozawaT Ogino
Apr 1, 1992·Seminars in Arthritis and Rheumatism·W V WilliamsD B Weiner

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