Human epidermal growth factor receptor 2 overexpression in breast cancer of patients with anti-Yo--associated paraneoplastic cerebellar degeneration.

Neuro-oncology
Iñigo Rojas-MarcosFrancesc Graus

Abstract

Isolated case reports suggest that breast tumors from patients with paraneoplastic cerebellar degeneration (PCD) and Yo antibodies overexpress human epidermal growth factor receptor 2 (HER2). HER2 overexpression is present in 15%-25% of breast cancers and is associated with poor prognosis. We retrospectively analyzed the status of HER2 in breast tumors of 27 patients with anti-Yo-associated PCD to evaluate whether HER2 overexpression in this group of patients is higher than expected. In addition, we analyzed HER2 status of 19 breast tumors from patients with paraneoplastic neurological syndromes and Ri antibodies to see whether HER2 was specifically related to anti-Yo-associated PCD. We also assessed cdr2 expression (the onconeural antigen recognized by Yo antibodies) in 21 HER2-positive breast tumors from patients without paraneoplastic neurological syndromes. HER2 was overexpressed in 26 patients (96.3%) with anti-Yo-associated PCD but only in 2 patients (10.5%) with paraneoplastic neurological syndromes associated with Ri antibodies (P< .0001). Only 5 (23.8%) of the 21 HER2-positive breast tumors showed cdr2 immunoreactivity. This study shows a very high frequency of HER2 overexpression in breast cancers in patients with ant...Continue Reading

References

Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F GrausF X Real
Jun 3, 1998·AJR. American Journal of Roentgenology·C Chartrand-LefebvreC Beigelman
Nov 6, 2001·Oncology·M PiccartD Larsimont
Oct 17, 2003·The New England Journal of Medicine·Robert B Darnell, Jerome B Posner
Jan 24, 2006·Cancer Immunology, Immunotherapy : CII·Anette KnudsenChristian A Vedeler
Mar 18, 2006·Clinical and Experimental Immunology·S E MonstadC A Vedeler
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Nov 8, 2007·PloS One·Marianne TuefferdSophie Camilleri-Broët
Nov 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bianca D SantomassoRobert B Darnell
Jan 1, 2007·Archives of Pathology & Laboratory Medicine·Antonio C WolffUNKNOWN American Society of Clinical Oncology/College of American Pathologists
Mar 10, 2010·Archives of Neurology·Bruno GiomettoUNKNOWN PNS Euronetwork
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Johan StaafAke Borg
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Annette LebeauMichael Untch
Nov 17, 2010·Cancer Immunology, Immunotherapy : CII·Cecilie TotlandChristian A Vedeler

❮ Previous
Next ❯

Citations

Apr 1, 2015·The Cerebellum·Hiroshi MitomaNobuhiro Yuki
Feb 28, 2014·Clinical & Developmental Immunology·Mikolaj Piotr Zaborowski, Slawomir Michalak
Jan 5, 2018·Acta Neuropathologica·Mathilde SmallVirginie Desestret
Aug 21, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Omer Fatih OlmezJamshid Hamdard
Mar 15, 2020·Neurology. Neuroimmunology and Neuroinflammation·Claire SimardJérôme Honnorat
Jun 15, 2018·British Journal of Cancer·Clément Vialatte de PémilleAgusti Alentorn
Jul 9, 2020·Therapeutic Advances in Neurological Disorders·Alberto VogrigJérôme Honnorat
Nov 9, 2021·Frontiers in Neurology·Christopher M BartleyMichael R Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved