Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase

The Journal of Investigative Dermatology
D von BubnoffHenri de la Salle

Abstract

Langerhans cells (LC) are a special subset of dendritic cells integrating cutaneous immunity. The study of LC function is of major interest not only for efforts of vaccine design and immunotherapy but also for gaining an insight into the pathogenesis of immune-mediated cutaneous diseases and neoplasias. Recently, defined antigen-presenting cells were described that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro and in vivo. Here, we show that stimulation with interferon-gamma (IFN-gamma) induces the expression of functionally active IDO in highly purified human epidermal LC. The induction of IDO after stimulation of LC with IFN-gamma seems to follow a defined kinetic with rapid upregulation followed by a downregulation after about 24 h of culture. Accordingly, proliferation of T cells induced by anti-CD3 antibodies was modulated by supernatants of IFN-gamma-activated human epidermal LC. Importantly, downregulation of T cell proliferation by supernatants of 24 h IFN-gamma-activated LC was prevented by inhibition of IDO. These results indicate that LC not only have the capacity to stimulate but also to inhibit T cells, and suggest that LC possess an immunoregulatory function in promoting T cel...Continue Reading

References

Feb 1, 1988·The Journal of Investigative Dermatology·C A PicutR M Lewis
Mar 1, 1985·The Journal of Experimental Medicine·G Schuler, R M Steinman
Jan 1, 1980·Immunological Reviews·G StinglS I Katz
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·S OkudaH Katsuki
Jul 20, 1999·Journal of Leukocyte Biology·B WangD N Sauder
Feb 28, 2002·Annual Review of Immunology·Pierre GuermonprezSebastian Amigorena
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Kristian ReichChristine Neumann
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dagmar von BubnoffThomas Bieber
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Sep 17, 2002·Cell Death and Differentiation·F FallarinoP Puccetti
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Nov 5, 2002·Nature Immunology·Miriam MeradEdgar G Engleman
May 3, 2003·Annals of the New York Academy of Sciences·Ralph M SteinmanMichel Nussenzweig
May 10, 2003·Trends in Immunology·Ursula GrohmannPaolo Puccetti
Jun 5, 2003·Current Molecular Medicine·Tsuneyasu Kaisho, Shizuo Akira
Jun 13, 2003·Pathologie-biologie·R M Steinman
Jul 9, 2003·The Journal of Allergy and Clinical Immunology·Jean-Pierre AllamThomas Bieber
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guang-Xian ZhangAbdolmohamad Rostami
Dec 20, 2003·Current Molecular Medicine·Tsuneyasu Kaisho, Shizuo Akira

❮ Previous
Next ❯

Citations

Apr 24, 2012·The Journal of Clinical Investigation·Mercedes Gomez de AgüeroBertrand Dubois
Jan 10, 2013·The Journal of Clinical Investigation·Juliana IdoyagaRalph M Steinman
Feb 21, 2009·Journal of Periodontology·Kanokwan NisapakultornOsamu Takikawa
Dec 1, 2009·Future Medicinal Chemistry·Stephanie KadowCharlotte Esser
Oct 14, 2008·Expert Opinion on Biological Therapy·Jianchao QuanPeter J Friend
Apr 20, 2011·Journal of the American Academy of Dermatology·Dagmar von BubnoffClaudia Wickenhauser
Dec 16, 2005·The Journal of Investigative Dermatology·Michael D RosenblumRobert L Truitt
Dec 7, 2007·The American Journal of Pathology·Marina SchelerDagmar von Bubnoff
Jan 8, 2009·Contact Dermatitis·Mascha J ToebakThomas Rustemeyer
Sep 18, 2008·The British Journal of Dermatology·K C MeyerR Paus
Jul 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Gros, N Novak
Apr 24, 2012·Allergy·D von Bubnoff, T Bieber
May 16, 2006·The International Journal of Biochemistry & Cell Biology·Carole L BergerRichard L Edelson
Jan 3, 2006·Journal of Dermatological Science·Michael D RosenblumRobert L Truitt
Apr 7, 2010·International Reviews of Immunology·Lei HuangAndrew L Mellor
Jan 8, 2015·Frontiers in Cellular and Infection Microbiology·Laurent GorvelJean-Louis Mege
Jan 31, 2017·The British Journal of Dermatology·Z XieY H Chen
Feb 16, 2006·Current Allergy and Asthma Reports·Annie V Le, David H Broide
Dec 30, 2006·Cancer Immunology, Immunotherapy : CII·Marion WobserJuergen C Becker
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexey Popov, Joachim L Schultze
Mar 10, 2010·Immunology and Cell Biology·Manfred B LutzHiroaki Azukizawa
Oct 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Botond Z IgyartoDaniel H Kaplan
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bettina JuxCharlotte Esser
Mar 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cedric LenormandSylvie Tourne
Feb 18, 2010·Immunotherapy·Burles A JohnsonAndrew L Mellor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.