Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer

Annals of Oncology : Official Journal of the European Society for Medical Oncology
D SantiniG Tonini

Abstract

Gemcitabine is an acceptable alternative to best supportive care in the treatment of advanced biliary tract cancers. The human equilibrative nucleoside transporter 1 (hENT1) is a ubiquitous protein and is the major means by which gemcitabine enters human cells. Moreover, recent reports indicate a significant correlation between immunohistochemical variations of hENT1 in tumor samples and survival after gemcitabine therapy in patients with solid tumors. We used immunohistochemistry to assess the abundance and distribution of hENT1 in tumor samples from radically resected cancer of the ampulla, and sought correlations between immunohistochemical results and clinical parameters including disease outcomes. In the 41 individual tumors studied, 12 (29.3%) had uniformly high hENT1 immunostaining. Statistical analysis showed a significant correlation between hENT1 and Ki-67 (P = 0.04). No statistical significant differences were found between immunohistochemical findings and patient characteristics (sex, age, and tumor-node-metastasis). On univariate analysis, hENT1 and Ki-67 expression were associated with overall survival (OS). Specifically, those patients with overexpression of hENT1 showed a shorter OS (P = 0.022) and those with hi...Continue Reading

Citations

Aug 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B VincenziG Tonini
May 25, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Z-Q JiangM J Overman
May 28, 2010·Pharmacogenomics·Ekaitz Errasti-Murugarren, Marçal Pastor-Anglada
Jun 6, 2009·World Journal of Gastroenterology : WJG·Ioannis A VoutsadakisChristos N Papandreou
Feb 26, 2010·Nucleosides, Nucleotides & Nucleic Acids·Vijaya L DamarajuCarol E Cass
Feb 26, 2015·Frontiers in Pharmacology·Marçal Pastor-Anglada, Sandra Pérez-Torras
Jul 12, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A LazaryanR Kim
Jan 19, 2010·Journal of Cellular Physiology·Daniele SantiniFrancesco Graziano
Jun 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kacper A WojtalStephan R Vavricka
Feb 3, 2011·Medicinal Research Reviews·Pedro Cano-Soldado, Marçal Pastor-Anglada
Dec 20, 2019·Pharmacological Reviews·Hermann Koepsell
Feb 10, 2011·Nature Reviews. Clinical Oncology·Joseph CiccoliniNicolas André
Nov 2, 2017·The Journal of Clinical Endocrinology and Metabolism·Judith E K HenningCristina L Ronchi
Feb 9, 2021·Neuro-oncology·Masahiro YamamotoChifumi Kitanaka

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