Human equilibrative nucleoside transporter 1 expression predicts survival of advanced cholangiocarcinoma patients treated with gemcitabine-based adjuvant chemotherapy after surgical resection

Annals of Surgery
Hironori KobayashiTaijiro Sueda

Abstract

The aim of this study was to evaluate whether intratumoral human equilibrative nucleoside transporter 1 (hENT1) expression can predict the survival of advanced cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy (AGC) after surgical resection. There have been no reports concerning a useful predictive biomarker in patients with cholangiocarcinoma treated with adjuvant gemcitabine chemotherapy. Intratumoral hENT1 expression was investigated immunohistochemically in 105 patients with resected advanced cholangiocarcinoma. Relationships between intratumoral hENT1 expression and clinicopathological factors were evaluated by univariate and multivariate analyses. This study was a retrospective analysis on retrospectively collected tissue and data. Fifty-one patients received AGC, and 54 did not. High and low intratumoral hENT1 expression was found in 74 (70%) and 31 patients (30%), respectively. There were no significant differences in clinicopathological factors between patients with high hENT1 expression and those with low hENT1 expression. Survival patients with high hENT1 expression were significantly better than those with low hENT1 expression among patients who received AGC (P = 0.008), but not among ...Continue Reading

References

Oct 1, 1996·Annals of Surgery·A NakeebJ L Cameron
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Apr 13, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PenzW Scheithauer
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer SpratlinJohn R Mackey
Sep 6, 2005·Cancer Chemotherapy and Pharmacology·Takuji OkusakaToshio Tsuyuguchi
Dec 21, 2005·Lasers in Surgery and Medicine·Paul J Wu, Joseph T Walsh
Jul 28, 2006·Japanese Journal of Clinical Oncology·Hideaki TsukumaUNKNOWN Research Group of Population-Based Cancer Registries of Japan
Feb 6, 2007·Journal of Surgical Oncology·Yoshiaki MurakamiTaijiro Sueda
Jan 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D SantiniG Tonini
Mar 28, 2008·American Journal of Surgery·Yoshiaki MurakamiTaijiro Sueda
Feb 21, 2009·Journal of the American College of Surgeons·Hauke LangChristoph E Broelsch
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raphaël MaréchalJean-Luc Van Laethem
May 8, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yoshiaki MurakamiTaijiro Sueda
Oct 7, 2009·Journal of Hepato-biliary-pancreatic Sciences·Tsuyoshi IgamiMasato Nagino
Oct 13, 2009·Journal of Hepato-biliary-pancreatic Sciences·Satoshi HiranoRyosuke Kawasaki
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Oct 15, 2010·Annals of Surgical Oncology·Yoshiaki MurakamiTaijiro Sueda

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Citations

Jun 26, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yoshiaki MurakamiTaijiro Sueda
Aug 3, 2013·Biomarkers in Medicine·Lars Petter Jordheim, Charles Dumontet
May 21, 2014·Langenbeck's Archives of Surgery·Irinel Popescu, Traian Dumitrascu
Aug 1, 2012·Journal of Gastroenterology·Masato Nagino
May 3, 2014·Journal of Gastroenterology and Hepatology·Jimme K WiggersThomas M van Gulik
Feb 26, 2015·Frontiers in Pharmacology·Marçal Pastor-Anglada, Sandra Pérez-Torras
May 25, 2016·Expert Opinion on Drug Metabolism & Toxicology·Joseph CiccoliniRaphaelle Fanciullino
Jan 15, 2017·Chinese Journal of Cancer·Young Saing KimSoon Chan Hong
Mar 12, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachna T ShroffShishir K Maithel
Sep 23, 2018·Journal of Gastroenterology and Hepatology·Keiichi AkahoshiMinoru Tanabe
Jan 1, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jason A Sprowl, Alex Sparreboom
Jul 12, 2017·Scientific Reports·Matthew J FoulkesStephen A Renshaw

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