Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy

Pancreas
Reiko YamadaShuji Isaji

Abstract

This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in 51 of 76 patients with PDAC who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. The concordance rate of hENT1 expressions was 89.2% (K = 0.681). Median survival time (month) in the 51 whole patients and 37 patients with resection was significantly longer in hENT1 positive than in hENT1 negative: 25.0 and 30.0 versus 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than...Continue Reading

References

Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Sep 16, 2004·Cancer·Mary R Schwartz
Dec 3, 2005·Journal of Gastroenterology·Kenji YamaoTakashi Koshikawa
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·J R MackeyC E Cass
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raphaël MaréchalJean-Luc Van Laethem
Oct 12, 2010·Neoplasia : an International Journal for Oncology Research·Hayato FujitaMasao Tanaka
Oct 21, 2011·Annals of Surgical Oncology·Angelo AndriulliPierluigi Di Sebastiano
Jan 18, 2012·Gastrointestinal Endoscopy·Michael Jonathan HewittKevin J Monahan
Dec 5, 2013·Journal of the National Cancer Institute·William GreenhalfUNKNOWN European Study Group for Pancreatic Cancer
Feb 14, 2014·Endoscopy·Takeshi OguraKazuhide Higuchi
May 27, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Steffen OrmannsStefan Boeck

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Citations

Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sven H LoosenTom Luedde
Jul 14, 2020·Endoscopic Ultrasound·Bojan Kovacevic, Peter Vilmann
Dec 5, 2019·World Journal of Gastrointestinal Oncology·Livia ArchibugiPaolo Giorgio Arcidiacono
Feb 18, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sumit SahniAnubhav Mittal
Jun 3, 2021·Cancer Cytopathology·Lucia Roa-PeñaKenneth R Shroyer
Aug 29, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yasuhiro MurataShuji Isaji

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Methods Mentioned

BETA
biopsy
pancreatectomy
surgical resection

Software Mentioned

SPSS

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