Dec 1, 1975

Human erythrocyte carbonic anhydrase B and C in chronic obstructive lung disease

The Tohoku Journal of Experimental Medicine
T KondoK Saito


The levels of carbonic anhydrase B and C isozymes in human red cells were determined using a quantitative immunological technique in patients with chronic obstructive lung disease. A significant increase in the level of carbonic anhydrase B was observed in these patients, while the level of carbonic anhydrase C did not change substantially. Positive correlations were found between the level of carbonic anhydrase B and arterial CO2 tension and plasma HCO3 concentration. A negative correlation was observed between the levels of carbonic anhydrase B and blood pH. These findings suggest that the synthesis or degradation of carbonic anhydrase B isozyme is affected by arterial CO2 tension or plasma HC03 concentration. The clinical significance was also discussed in relation to these isozyme levels in red cell.

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Mentioned in this Paper

CA2 gene
Immune Sera
Carbonic Acid Ions
Carbonic Anhydrase I
Gases, Blood, pH Only
Lung Diseases, Obstructive
Carbonic Anhydrase II
Antibody Dissociation
Blood pH

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