PMID: 8954296Jan 1, 1996Paper

Human erythropoietin response to hypocapnic hypoxia, normocapnic hypoxia, and hypocapnic normoxia

European Journal of Applied Physiology and Occupational Physiology
T KlausenN V Olsen

Abstract

This study investigated the human erythropoietin (EPO) response to short-term hypocapnic hypoxia, its relationship to a normoxic or hypoxic increase of the haemoglobin oxygen affinity, and its suppression by the addition of CO2 to the hypoxic gas. On separate days, eight healthy male subjects were exposed to 2 h each of hypocapnic hypoxia, normocapnic hypoxia, hypocapnic normoxia, and normal breathing of room air (control experiment). During the control experiment, serum-EPO showed significant variations (ANOVA P = 0.047) with a 15% increase in mean values. The serum-EPO measured in the other experiments were corrected for these spontaneous variations in each individual. At 2 h after ending hypocapnic hypoxia (10% O2 in nitrogen), mean serum-EPO increased by 28% [baseline 8.00 (SEM 0.84) U.l-1, post-hypoxia 10.24 (SEM 0.95) U.l-1, P = 0.005]. Normocapnic hypoxia was produced by the addition of CO2 (10% Co2 with 10% O2) to the hypoxic gas mixture. This elicited an increased ventilation, unaltered arterial pH and haemoglobin oxygen affinity, a lower degree of hypoxia than during hypocapnic hypoxia, and no significant changes in serum-EPO (ANOVA P > 0.05). Hypocapnic normoxia, produced by hyperventilation of room air, elicited a n...Continue Reading

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Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·T KlausenN V Olsen

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Citations

Jul 9, 2005·European Journal of Applied Physiology·Dag HofsøEinar Thorsen
Oct 7, 2005·Pflügers Archiv : European journal of physiology·Carsten WillamKai-Uwe Eckardt
Feb 13, 2009·Diabetes Research and Clinical Practice·Peter Lommer KristensenBirger Thorsteinsson
May 1, 2007·Respiratory Physiology & Neurobiology·H-C GungaW Schobersberger
Feb 3, 2006·Acta Anaesthesiologica Scandinavica·N V Olsen
Oct 7, 2020·International Journal of Environmental Research and Public Health·Mercedes J NagelSophie Lalande
Feb 27, 2003·The Journal of Experimental Biology·Robert A MacArthurKevin L Campbell
May 7, 2021·Journal of Applied Physiology·Frank WojanSophie Lalande

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