PMID: 590306Nov 14, 1977

Human experience of cetiedil, a new vasodilator with anticholinergic properties

European Journal of Clinical Pharmacology
A M SoeterboekH Wesseling

Abstract

Cetiedil, a new vasodilating drug with anticholinergic properties, was shown to be metabolised very rapidly in man after intravenous and oral administration of the 14C-compound. Higher concentrations of labelled compound after oral than after intravenous administration at the same sampling time, and proportional differences in urinary excretion, suggest that metabolic handling of the drug differs depending on the route of administration. Experiments in which inhibition of saliva secretion was measured indicated that (an) active metabolite(s) probably was (were) responsible for the action of the drug. As an anticholinergic drug, cetiedil is at least 400 times weaker than atropine.

References

May 21, 1970·The New England Journal of Medicine·L C McHenryH I Goldberg

Citations

Jan 1, 1989·Annals of the New York Academy of Sciences·L J Benjamin
Aug 1, 1987·Journal of Neurochemistry·Y M Gaudry-TalarmainN Morel
Jun 11, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Michele R S SimõesMarcos J Yokoo

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