Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm

Environmental Epigenetics
Adelheid SoubryHeather M Stapleton

Abstract

Emerging evidence suggests that early exposure to endocrine disrupting chemicals has long-term consequences that can influence disease risk in offspring. During gametogenesis, imprinted genes are reasonable epigenetic targets with the ability to retain and transfer environmental messages. We hypothesized that exposures to organophosphate (OP) flame-retardants can alter DNA methylation in human sperm cells affecting offspring's health. Sperm and urine samples were collected from 67 men in North Carolina, USA. Urinary metabolites of a chlorinated OP, tris(1,3-dichloro-2-propyl) phosphate, and two non-chlorinated OPs, triphenyl phosphate and mono-isopropylphenyl diphenyl phosphate, were measured using liquid-chromatography tandem mass-spectrometry. Sperm DNA methylation at multiple CpG sites of the regulatory differentially methylated regions (DMRs) of imprinted genesGRB10,H19,IGF2,MEG3,NDN,NNAT,PEG1/MEST,PEG3,PLAGL1,SNRPN, andSGCE/PEG10was quantified using bisulfite pyrosequencing. Regression models were used to determine potential associations between OP concentrations and DNA methylation. We found that men with higher concentrations of urinary OP metabolites, known to originate from flame-retardants, have a slightly higher frac...Continue Reading

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Citations

May 8, 2018·Environmental Epigenetics·Adelheid Soubry
Nov 18, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Ross GilletteDavid Crews
Feb 26, 2019·Basic & Clinical Pharmacology & Toxicology·Michelle Kira Lee, Bruce Blumberg
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Nov 16, 2020·Trends in Genetics : TIG·Ali JawaidIsabelle M Mansuy
May 11, 2021·Frontiers in Endocrinology·Adelheid SoubryCathrine Hoyo
May 1, 2021·Biology of Reproduction·Millissia Ben MaamarMichael K Skinner
Nov 19, 2021·Biochemical Genetics·Meenu Ghai, Farzeen Kader
Dec 17, 2021·Nature Reviews. Endocrinology·Niels E SkakkebækAnders Juul

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