Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?

Archives of Toxicology
Herman AutrupNico P Vermeulen

Abstract

Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC expo...Continue Reading

References

Apr 1, 1995·Environmental Health Perspectives·S H Safe
Mar 10, 1998·Proceedings of the Society for Experimental Biology and Medicine·C H IrvineS L Alexander
Apr 29, 1998·Critical Reviews in Toxicology·R J GoldenE A Reese
Jun 22, 2000·Toxicologic Pathology·R Nilsson
Oct 18, 2002·Regulatory Toxicology and Pharmacology : RTP·Raphael J Witorsch
Aug 16, 2005·Critical Reviews in Toxicology·Robert GoldenGuenter Vollmer
Jun 20, 2006·Reproductive Toxicology·Elena MenegolaErminio Giavini
Mar 30, 2010·Frontiers in Neuroendocrinology·Heather B Patisaul, Wendy Jefferson
Oct 12, 2010·Critical Reviews in Toxicology·Raphael J Witorsch, John A Thomas
Oct 27, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary Sue MartyJustin Craig Rowlands
May 3, 2011·Archives of Toxicology·Sarah AdlerJosé-Manuel Zaldivar
Nov 8, 2011·Regulatory Toxicology and Pharmacology : RTP·C J BorgertR J Golden
Apr 11, 2012·Environmental Toxicology and Chemistry·Daniel J CaldwellJohn P Sumpter
Oct 3, 2012·Handbook of Experimental Pharmacology·A CleveT Wintermantel
Nov 6, 2012·Steroids·Kristy K Michael MillerRussell A Prough
Jul 11, 2013·Regulatory Toxicology and Pharmacology : RTP·Christopher J BorgertJohn C Matthews
Jul 16, 2013·Regulatory Toxicology and Pharmacology : RTP·Daniel R DietrichAlan Harvey
Oct 22, 2013·Toxicology Letters·Bennard van RavenzwaayHenk Vrijhof
Nov 2, 2013·Toxicology Letters·Gerhard J NohynekKarl K Rozman
Jun 1, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Herman AutrupNico P Vermeulen
Feb 4, 2016·Archives of Toxicology·Daniel R Dietrich, Jan G Hengstler
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Gio Batta Gori, Wolfgang Dekant
Sep 13, 2016·Regulatory Toxicology and Pharmacology : RTP·Herman N AutrupHiroshi Yamazaki
Oct 21, 2016·British Journal of Pharmacology·Ivonne M C M RietjensKarsten Beekmann
Mar 16, 2017·Environmental Toxicology and Pharmacology·Stavros SifakisDemetrios A Spandidos
May 31, 2017·Current Opinion in Obstetrics & Gynecology·Lidia Mínguez-Alarcón, Audrey J Gaskins
Apr 11, 2018·Archives of Toxicology·Christopher J BorgertStephen P Baker
Dec 29, 2018·Critical Reviews in Toxicology·Gerard M H SwaenMaurice Zeegers

❮ Previous
Next ❯

Citations

Jul 3, 2021·International Journal of Environmental Research and Public Health·Aleksandra FucicJohn E Vena

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception

Software Mentioned

REACH

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Herman AutrupNico P Vermeulen
© 2022 Meta ULC. All rights reserved