PMID: 9537610Apr 16, 1998Paper

Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar

The American Journal of Clinical Nutrition
L C HudginsJ Hirsch

Abstract

Using new nonisotopic and isotopic methods, we showed previously that fatty acid synthesis was markedly stimulated in weight-stable normal volunteers by a very-low-fat formula diet with 10% of energy as fat and 75% as short glucose polymers. In this study, we determined whether fatty acid synthesis was equally stimulated by a very-low-fat solid diet made with foods consumed typically. Four normal volunteers consumed the same very-low-fat formula diet for 25 d and then an isoenergetic solid food diet with 10% of energy as fat and 75% as starch, simple sugars, and fiber for 25 d. To measure fatty acid synthesis, the fatty acid compositions of the diets were matched to the composition of each subject's adipose tissue and compared with the composition of VLDL-triacylglycerol. In all subjects, the large increases in newly formed palmitate and decreases in linoleate in VLDL-triacylglycerol were quickly reversed by the solid food diet, and the fraction of de novo synthesized fatty acids in fasting VLDL-triacylglycerol decreased from 30-54% to 0-1%. In a second group of subjects, the stimulation of fatty acid synthesis by the formula diet with 75% glucose polymers was similarly reduced by a formula diet with amounts of fat, starch, and...Continue Reading

Citations

Aug 17, 1999·Annual Review of Nutrition·S M Grundy
Oct 19, 1999·The Journal of Clinical Investigation·E J ParksM K Hellerstein
Jun 6, 2000·The American Journal of Clinical Nutrition·S E Kasim-KarakasJ Peerson
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Michel Beylot
May 10, 2017·Current Medicinal Chemistry·Caroline S StokesMarcin Krawczyk
Nov 16, 2018·BMJ : British Medical Journal·Cara B EbbelingDavid S Ludwig
Feb 10, 2019·Journal of Lipid Research·Jihong LianRichard Lehner
Jul 18, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·L Tappy, K Minehira
Jan 29, 2000·The American Journal of Clinical Nutrition·E J Parks, M K Hellerstein
Feb 7, 2001·The American Journal of Clinical Nutrition·I Marques-LopesJ A Martínez
Nov 28, 2001·The American Journal of Clinical Nutrition·R M McDevittA M Prentice
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
Mar 9, 2007·The Proceedings of the Nutrition Society·Mary F F ChongKeith N Frayn
Apr 11, 2008·The American Journal of Clinical Nutrition·Mary F-F ChongBarbara A Fielding
Nov 24, 1999·Nutrition Reviews·K L Morris, M B Zemel
Mar 10, 2001·The American Journal of Clinical Nutrition·P H BisschopJ A Romijn
Nov 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·R H KnoppB McCann
Nov 10, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Luc Tappy
Jan 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Lisa C HudginsMarc K Hellerstein
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·E F CoyleT W Zderic
May 16, 2014·Advances in Nutrition·Maren R LaughlinPadma Maruvada
Oct 4, 2002·Current Atherosclerosis Reports·Simin Liu, Walter C Willett
Jan 11, 2005·The American Journal of Clinical Nutrition·Maureen T Timlin, Elizabeth J Parks
Aug 11, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K MinehiraL Tappy
Nov 26, 2020·Current Opinion in Lipidology·Kay H M RoumansVera B Schrauwen-Hinderling
Dec 22, 2020·Molecular Metabolism·Kendra K Bence, Morris J Birnbaum
Nov 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·L C Hudgins
Oct 3, 2003·The American Journal of Clinical Nutrition·Susan K Fried, Salome P Rao

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