Human fetal membranes inhibit calcium L-channel activated uterine contractions

American Journal of Obstetrics and Gynecology
P L CollinsT M Kulp

Abstract

Paracrine signals among fetal membranes, decidua, and uterus play an important role in the initiation of parturition in women. In previous work we demonstrated that fetal membranes inhibit uterine contractions. In the current study we test the hypothesis that the fetal membranes decrease uterine contractions by inhibition of the uterine calcium L-channel. Our dual-chamber fetal membrane-uterine muscle in vitro model was used in this study. Rat uterine muscle strips were anchored into the maternal sides of the chambers. Fetal membranes (or Parafilm controls) were added to the chamber in a removable cassette. Uterine contractions were stimulated with the specific calcium L-channel agonist Bay K 8644. When uterine muscle was exposed to full-thickness fetal membranes (amnion-chorion with attached decidua) or to the intact fetal components (chorion-amnion) or to chorion alone, the Bay K 8644 dose-response curve was significantly shifted to the right. When uterine muscle was exposed to amnion alone or to the decidua alone, the Bay K 8644 dose-response curve was not shifted. Fetal membranes, did not cause a shift in the ionomycin (a calcium ionophore) dose-response curve. These results support the hypothesis and provide evidence that ...Continue Reading

References

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Apr 1, 1995·American Journal of Obstetrics and Gynecology·P L CollinsJ J Moore

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Citations

Jun 30, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lampros PapandreouTheodor Stefos
Oct 28, 1998·American Journal of Obstetrics and Gynecology·S P EmeryP L Collins
Mar 3, 2001·American Journal of Obstetrics and Gynecology·E M CarrollP L Collins
Jul 4, 2006·Journal of the Society for Gynecologic Investigation·Jorge A CarvajalCarl P Weiner
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Si-Eun LeeYoung-Ho Lee
Nov 6, 1998·Pediatric Research·R K Riemer, M A Heymann
May 10, 2002·Obstetrical & Gynecological Survey·Sheryl Rodts-Palenik, John C Morrison

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