Human fetal right ventricular ejection force under abnormal loading conditions during the second half of pregnancy

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
J RäsänenJ C Huhta

Abstract

Our objective was to determine whether abnormal loading conditions can modify human fetal right ventricular ejection force during the second half of pregnancy. By Doppler echocardiography, we studied 73 normal fetuses between 19 and 41 weeks of gestation, 27 fetuses with hypoplastic left heart syndrome (chronic volume overload) between 18 and 38 weeks of gestation, 14 fetuses with mild to moderate constriction of the ductus arteriosus (pulsatility index (PI) between 1.0 and 1.9) and seven fetuses with severe constriction (PI < 1.0) or occlusion of the ductus arteriosus (relatively acute pressure overload) between 28 and 34 weeks of gestation. In the normal and ductal constriction/occlusion groups, blood velocity waveforms were recorded at the level of the aortic and pulmonary valves, and in the group with hypoplastic left heart syndrome at the level of the pulmonary valve. The ventricular ejection forces were calculated. In the normal group, right (RVEF; r = 0.91, p < 0.0001) and left (LVEF; r = 0.86, p < 0.0001) ventricular ejection forces increased and were equal during the second half of gestation. In the group with hypoplastic left heart syndrome the RVEF increased (r = 0.76, p < 0.0001) with advancing gestation. The RVEF (...Continue Reading

Citations

Nov 29, 2001·Journal of Perinatal Medicine·J C Huhta
May 15, 2013·The Canadian Journal of Cardiology·Varsha ThakurEdgar T Jaeggi
Oct 7, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K MäkikallioJ Räsänen
Mar 28, 2009·The Annals of Thoracic Surgery·Anita SzwastJack Rychik
Mar 28, 2009·The Annals of Thoracic Surgery·Jennifer C Hirsch
Dec 9, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A WlochG Acharya
Sep 27, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L PasquiniN M Fisk
Feb 27, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A GirsenJ Räsänen
Oct 1, 2011·The Journal of Obstetrics and Gynaecology Research·Rajeswari ParasuramanDavid T Howe
Dec 30, 2017·Echocardiography·Luke Eckersley, Lisa K Hornberger
Oct 13, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T MiyoshiN Minamino
Sep 14, 2019·Annals of Pediatric Cardiology·Elaheh Malakan RadAli Akbar Zeinaloo

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