Human FGF-1 gene transfer promotes the formation of collateral vessels and arterioles in ischemic muscles of hypercholesterolemic hamsters

The Journal of Gene Medicine
Alexis CaronFlorence Emmanuel

Abstract

Acidic fibroblast growth factor (FGF-1) has been identified as a potent mitogen for vascular cells, inducing formation of mature blood vessels in vitro and in vivo and represents one of the most promising approaches for the treatment of ischemic cardiovascular diseases by gene therapy. Nevertheless, and most probably due to the few experimental models able to address the issue, no study has described the therapeutic effects of FGF-1 gene transfer in subjects with peripheral arterial disease (PAD) exhibiting a clinically relevant cardiovascular pathology. In order to assess the potency of FGF-1 gene transfer for therapeutic angiogenesis in ischemic skeletal muscles displaying decreased gene expression levels and sustained impaired formation of collateral vessels and arterioles, we developed a model of PAD in hamsters with a background of hypercholesterolemia. Hamsters fed a cholesterol-rich diet and subjected to hindlimb ischemia exhibit a sustained impaired angiogenic response, as evidenced by decreased angiographic score and histological quantification of arterioles in the ischemic muscles. In this model, we demonstrate that NV1FGF (a human FGF-1 expression plasmid), given intramuscularly 14 days after induction of hindlimb is...Continue Reading

Citations

Apr 5, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sigrid NikolUNKNOWN TALISMAN 201 investigators
Feb 26, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Iris BaumgartnerPia Delaère
Sep 1, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gaëlle VandermeulenVéronique Préat
Jan 4, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bernhard WitzenbichlerJeffrey M Isner
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·B L W BendermacherM H Prins
Oct 18, 2014·The Journal of Gene Medicine·Verena ProkoschSigrid Nikol
Jun 24, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E Van BelleJ Belch
Nov 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ta-Chiang LinShan-Hui Hsu
Aug 6, 2008·Journal of Leukocyte Biology·Melany C van OostromImo E Hoefer
May 30, 2021·Journal of Cardiovascular Translational Research·Juline N DeppenRebecca D Levit

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