PMID: 8940292Nov 1, 1996Paper

Human fibrinogen: anticipating a 3-dimensional structure

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
R F DoolittleG Spraggon

Abstract

The principal component of blood clots is a protein meshwork called fibrin. The precursor protein, fibrinogen, occurs in a soluble form in the blood plasma where it is activated by thrombin when and if the need arises. More than a century after first being purified, fibrinogen has yet to have its detailed 3-dimensional structure revealed. The situation is changing rapidly, however, and crystallographic studies in progress in several laboratories on a variety of fragments and complexes may soon reveal not only its structure but also the subtleties of how this large glycoprotein is transformed into a fibrin clot.

Citations

Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H BrownC Cohen
Jul 20, 2001·Annals of the New York Academy of Sciences·R F DoolittleI Mochalkin
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·K P PrattE W Davie
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·J MadrazoC Cohen
Aug 31, 2006·Biochemistry·Yugong ChengVladimir N Uversky
Jan 23, 1999·Current Opinion in Structural Biology·R F DoolittleS J Everse
Jan 14, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Leonore C DijkgraafStephen B Milam
Mar 21, 2003·Biophysical Chemistry·Russell F Doolittle

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