Human follicular dendritic cells interact with T cells via expression and regulation of cyclooxygenases and prostaglandin E and I synthases

The Journal of Immunology : Official Journal of the American Association of Immunologists
In Yong LeeJongseon Choe

Abstract

PGE(2) inhibits mature T cell proliferation and protects T cells from activation-induced cell death (AICD). We have previously demonstrated that human follicular dendritic cells (FDC) strongly express PGI synthase. In this study, the hypothesis that FDC have regulatory roles on germinal center T cells by controlling production of PGE(2) and PGI(2) was tested. Confocal microscopic analyses of human tonsil tissues revealed that FDC indeed expressed PGE synthase in addition to PGIS. To confirm these results, we studied the regulation mechanism of PG production in FDC, using an established human FDC-like cell line, HK. Specifically in response to TNF-alpha, TGF-beta, and LPS, protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed. The increase of these enzymes was reflected in actual production of PGE(2) and PGI(2). Interestingly, IL-4 almost completely abrogated the stimulatory activity of TNF-alpha, TGF-beta, and LPS in PG production. Furthermore, the up-regulation of PGE(2) and PGI(2) production was markedly down-regulated by indomethacin and a selective COX-2 inhibitor. PGI(2) analog and PGE(2) inhibited proliferati...Continue Reading

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Citations

Nov 30, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jungtae KimInchul Lee
Sep 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masaki MagariHitoshi Ohmori
Feb 13, 2013·Immunology·Johannes J KovarikGerhard J Zlabinger
Oct 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumiaki KojimaLeslie J Crofford
Apr 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Whajung ChoJongseon Choe
Feb 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jini KimJongseon Choe
Mar 28, 2019·Frontiers in Microbiology·Jayashree A Chandrasekharan, Neelam Sharma-Walia
Mar 7, 2021·Microorganisms·Muriel DresenAndreas Nerlich

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