Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2.

Fertility and Sterility
Ikuko K Bentsi-BarnesMargareta D Pisarska

Abstract

FOXL2 is expressed in granulosa cells (GC) of small and medium ovarian follicles, functions as a repressor of the human steroidogenic acute regulatory gene, a marker of a GC differentiation, and its mutation is associated with premature ovarian failure (POF) in women with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), type I. We now report that FOXL2 also represses the transcription of aromatase, P450scc, and cyclin D2, three other key genes involved in GC proliferation, differentiation, and steroidogenesis, and that a FOXL2 mutation found in patients with BPES type I, also fails to repress aromatase transcription, further supporting a role for FOXL2 in follicle maturation.

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Citations

Sep 21, 2013·General and Comparative Endocrinology·Berta CrespoAna Gómez
Apr 22, 2010·American Journal of Physiology. Endocrinology and Metabolism·Margareta D PisarskaGillian M Barlow
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Feb 23, 2018·Endocrinology·Martina BelliShunichi Shimasaki
Sep 21, 2013·Journal of Molecular Endocrinology·Adrien GeorgesReiner A Veitia
May 8, 2010·Nature Medicine·Bruce D Murphy
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Jul 10, 2020·Cancer Research·Stine E Weis-BankePaul A C Cloos
Aug 4, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Jun WuDi Wang

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