Human fronto-tectal and fronto-striatal-tectal pathways activate differently during anti-saccades.

Frontiers in Human Neuroscience
Antoin D de WeijerS F W Neggers

Abstract

Almost all cortical areas in the vertebrate brain take part in recurrent connections through the subcortical basal ganglia (BG) nuclei, through parallel inhibitory and excitatory loops. It has been suggested that these circuits can modulate our reactions to external events such that appropriate reactions are chosen from many available options, thereby imposing volitional control over behavior. The saccade system is an excellent model system to study cortico-BG interactions. In this study two possible pathways were investigated that might regulate automaticity of eye movements in the human brain; the cortico-tectal pathway, running directly between the frontal eye fields (FEF) and superior colliculus (SC) and the cortico-striatal pathway from the FEF to the SC involving the caudate nucleus (CN) in the BG. In an event-related functional magnetic resonance imaging (fMRI) paradigm participants made pro- and anti-saccades. A diffusion tensor imaging (DTI) scan was made for reconstruction of white matter tracts between the FEF, CN and SC. DTI fiber tracts were used to divide both the left and right FEF into two sub-areas, projecting to either ipsilateral SC or CN. For each of these FEF zones an event-related fMRI timecourse was extra...Continue Reading

Citations

Jan 14, 2016·NeuroImage. Clinical·Alexandra L BorstadDeborah S Nichols-Larsen
May 1, 2013·Neuroscience and Biobehavioral Reviews·Ilana J Bennett, Bart Rypma
Nov 11, 2014·Autism Research : Official Journal of the International Society for Autism Research·Aarthi PadmanabhanBeatriz Luna
Apr 5, 2013·Alcoholism, Clinical and Experimental Research·Courtney R GreenJames N Reynolds
May 10, 2018·Frontiers in Neurology·Elena PretegianiAlessandra Rufa

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