PMID: 9161602May 1, 1997Paper

Human GABAA receptor alpha 1 and alpha 3 subunits genes and alcoholism

Alcoholism, Clinical and Experimental Research
A Parsian, C R Cloninger

Abstract

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. GABA effects are largely mediated by binding to the postsynaptic GABAA receptor, causing the opening of an integral chloride-ion channel. The GABAA antagonists picrotoxin and bicuculline reduce some ethanol-induced behaviors, such as motor impairment, sedation, and hypnosis. The role of this receptor in alcoholism is further supported by effective alleviation of alcohol withdrawal symptoms by GABAA agonists. To determine the role of the GABAA receptor (GABR) genes in the development of alcoholism, we have used alpha 1 and alpha 3 simple sequence repeat polymorphisms in a sample of unrelated alcoholics, alcoholic probands with both parents, and psychiatrically normal controls. For the GABR alpha 1 gene, the differences between allele frequencies, when all alleles were compared together, were not significant between total alcoholics, subtypes of alcoholics, and normal controls. However, for GABR alpha 3, the differences between total alcoholics and normal controls were significant when all alleles were compared together. The differences between subtypes of alcoholics and normal controls were not significant. The results of haplotype relative ris...Continue Reading

Citations

Mar 29, 2001·Current Psychiatry Reports·M A Enoch, D Goldman
Dec 19, 1998·Psychiatry Research·E P NobleR S Sparkes
Dec 3, 1999·Brain Research. Molecular Brain Research·W Mu, D R Burt
Jul 22, 1998·Progress in Neurobiology·C L FaingoldA Riaz
Aug 22, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Mary-Anne Enoch
Sep 22, 1999·American Journal of Medical Genetics·A Parsian, Z H Zhang

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