PMID: 2504874Sep 1, 1989Paper

Human gamma interferon strongly upregulates its own gene expression in peripheral blood lymphocytes

The Journal of Experimental Medicine
K J Hardy, T Sawada

Abstract

The product of the human IFN-gamma gene was found to be a powerful upregulatory stimulus for its own gene expression in lectin-activated human PBMC. The INF-gamma autosuperinduction response was further enhanced by "priming" PBMC with IFN-gamma. Primed cells maximally upregulated their levels of IFN-gamma specific mRNA 4-fold faster and more than 20-fold higher than mock-stimulated cells. High mRNA levels persisted for several days after stimulation, and enhanced secretion of biologically active IFN-gamma paralleled the observed upregulation of gene expression. Producer cells demonstrating this response were found to be primarily localized to the rosette E- (leu 11+) fraction of PBMC and appear to be of the LGL/NK variety. Whether the autosuperinduction phenomenon occurs through direct or indirect effects of IFN-gamma on producer cells is still unclear. These results may be important both to an understanding of the pathogenesis of immune dysfunction and to the design of more effective immunotherapy.

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Citations

Apr 1, 1991·Developmental Biology·M E BarishS S Raissdana
Jan 1, 1990·Pharmacology & Therapeutics·H A Young, K J Hardy
Jan 1, 1993·Transplant Immunology·P F HalloranJ Madrenas
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M MalaguarneraB A Trovato
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J H PangL M Ching
Oct 1, 1998·Cytokine & Growth Factor Reviews·S Gessani, F Belardelli
May 31, 2001·International Immunopharmacology·A J Español, M E Sales
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki ShimizuM Wayne Flye
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Troye-BlombergP Perlmann
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G MartinoL M Grimaldi
May 1, 1994·The Journal of Experimental Medicine·P Di MarzioS Gessani
Jan 19, 2007·Journal of Virology·Isaac G SakalaGunasegaran Karupiah
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Jul 1, 1993·Journal of Neuroimmunology·C Z LuB G Arnason
Feb 12, 1998·The Journal of Experimental Medicine·H NeumannH Wekerle
Mar 26, 2005·Immunological Reviews·Roberto BaccalaArgyrios N Theofilopoulos
Jan 21, 2014·The Biochemical Journal·Qixue WangJihong Han
Aug 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Minlu HuLisa C Rohan
Dec 18, 2001·European Journal of Immunology·S ThorntonR Hirsch
Jul 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergey A TarasovOleg I Epstein
Jun 6, 2019·Cellular and Molecular Life Sciences : CMLS·Sameeksha ChopraAntoine Dufour
Jul 24, 2014·Immunology·Nicola L D Smith, David W Denning

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