Human Genetic Variability Contributes to Postoperative Morphine Consumption.

The Journal of Pain : Official Journal of the American Pain Society
Manuela De GregoriMassimo Allegri

Abstract

High interindividual variability in postoperative opioid consumption is related to genetic and environmental factors. We tested the association between morphine consumption, postoperative pain, and single nucleotide polymorphisms (SNPs) within opioid receptor μ 1 (OPRM1), catechol-O-methyltransferase (COMT), uridine diphosphate glucose-glucuronosyltransferase-2B7, and estrogen receptor (ESR1) gene loci to elucidate genetic prediction of opioid consumption. We analyzed 20 SNPs in 201 unrelated Caucasian patients who underwent abdominal surgery and who were receiving postoperative patient-controlled analgesia-administered morphine. Morphine consumption and pain intensity were dependent variables; age and sex were covariates. A haplotype of 7 SNPs in OPRM1 showed significant additive effects on opioid consumption (P = .007); a linear regression model including age and 9 SNPs in ESR1, OPRM1, and COMT explained the highest proportion of variance of morphine consumption (10.7%; P = .001). The minimal model including 3 SNPs in ESR1, OPRM1, and COMT explained 5% of variance (P = .007). We found a significant interaction between rs4680 in COMT and rs4986936 in ESR1 (P = .007) on opioid consumption. SNPs rs677830 and rs540825 of OPRM1 an...Continue Reading

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Citations

Jan 14, 2017·Basic & Clinical Pharmacology & Toxicology·Lecia M NielsenAnne E Olesen
Oct 25, 2017·Pharmacogenomics·Louise Ladebo, Anne Estrup Olesen
Oct 11, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Anna K M PerssonJonas Åkeson
Sep 22, 2018·Current Opinion in Anaesthesiology·Senthil PackiasabapathySenthilkumar Sadhasivam
Nov 20, 2016·Anesthesia and Analgesia·Harriet W Hopf
Jun 19, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Timothy J Genovese, Jun J Mao
Jul 31, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Shuai ZhaoYuan Zhang
Dec 20, 2018·Frontiers in Pharmacology·Shuqin ZhouR Stephanie Huang
Jul 28, 2020·Cancers·Dario BugadaMassimo Allegri
Jul 15, 2017·Frontiers in Neuroendocrinology·Donna L Maney
Jul 3, 2021·The International Journal of Neuropsychopharmacology·Andi LiuZhongming Zhao
Aug 23, 2019·Journal of Clinical Anesthesia·I-Wen ChenKuo-Chuan Hung

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