Human Genetic Variation and HIV/AIDS in Papua New Guinea: Time to Connect the Dots

Current HIV/AIDS Reports
Rajeev K Mehlotra

Abstract

Human genetic polymorphisms known to influence HIV acquisition and disease progression occur in Papua New Guinea (PNG). However, no genetic association study has been reported so far. In this article, we review research findings, with a view to stimulate genotype-to-phenotype research. PNG, a country in Oceania, has a high prevalence of HIV and many sexually transmitted infections. While limited data is available from this country regarding the distribution of human genetic polymorphisms known to influence clinical outcomes of HIV/AIDS, genetic association studies are lacking. Our studies, in the past decade, have revealed that polymorphisms in chemokine receptor-ligand (CCR2-CCR5, CXCL12), innate immune (Toll-like receptor, β-defensin), and antiretroviral drug-metabolism enzyme (CYP2B6, UGT2B7) genes are prevalent in PNG. Although our results need to be validated in further studies, it is urgent to pursue large-scale, comprehensive genetic association studies that include these as well as additional genetic polymorphisms.

References

Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GonzalezS K Ahuja
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·E GonzalezS K Ahuja
Dec 14, 2004·Human Genomics·Vanessa J Clark, Michael Dean
Jan 5, 2005·The Journal of Infectious Diseases·Richard A KaslowJames Jianming Tang
Mar 1, 2006·European Journal of Clinical Pharmacology·Rajeev K MehlotraPeter A Zimmerman
Feb 16, 2007·AIDS·Pierre-Yves BochudUNKNOWN Swiss HIV Cohort Study
Mar 30, 2007·British Journal of Clinical Pharmacology·Rajeev K MehlotraPeter A Zimmerman
Aug 7, 2007·AIDS Research and Human Retroviruses·Claire E RyanRobert B Oelrichs
Jan 31, 2008·Clinical Science·E Ann Misch, Thomas R Hawn
Sep 5, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Natalia Soriano-SarabiaManuel Leal
Feb 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michele MilaneseSergio Crovella
Mar 26, 2009·Malaria Journal·Jennifer A GreeneJames W Kazura
Jun 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anne-Sophie BélangerChantal Guillemette
Dec 17, 2009·Expert Opinion on Drug Metabolism & Toxicology·Natella Y Rakhmanina, John N van den Anker
May 7, 2010·Genes and Immunity·M GrothM Platzer
May 27, 2010·Journal of Translational Medicine·Elisabetta RicciAnita De Rossi
Jul 8, 2010·American Journal of Physical Anthropology·Esther J LeeD Andrew Merriwether
Jul 8, 2011·Current Opinion in HIV and AIDS·Magdalena E SobieszczykM Juliana McElrath
Sep 17, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ben CoghlanMike Toole

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