Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis

Frontiers in Immunology
Ximei ZhangSong Guo Zheng

Abstract

Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE-/- mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages in vitro. Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis.

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Citations

Nov 9, 2019·Current Stem Cell Research & Therapy·Xudong Gao, Zhengguo Cao
Mar 9, 2019·Translational Stroke Research·Wei CaiZhengqi Lu
Jun 7, 2020·Stem Cell Research & Therapy·Ying LinXiaomin Chen
Aug 15, 2020·Frontiers in Immunology·Gholamreza DaryaborKurosh Kalantar
Mar 2, 2021·Medicinal Research Reviews·Bruna C GalgaroMárcia R Wink
Mar 16, 2021·Frontiers in Pharmacology·Wumei WeiXiaohong Tian
Apr 19, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wenbin WuSong Guo Zheng
May 27, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R M HashemK S Hashem
Aug 10, 2021·Frontiers in Immunology·Xueying ZhangJincheng Zeng
Jul 25, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wenbin WuSong Guo Zheng
Dec 18, 2021·Journal of Extracellular Vesicles·Su-Ran LiGang Chen
Dec 26, 2021·Journal of Cellular and Molecular Medicine·Xiaohong TianQiang Ao
Jan 5, 2022·Journal of Leukocyte Biology·Jiani LiuFulan Wei

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Methods Mentioned

BETA
FACS
PMA
Protein Assay
electrophoresis
flow cytometry
ELISA

Software Mentioned

GraphPad Prism
ZEN
ImageJ

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