PMID: 2504938Sep 1, 1989Paper

Human glial cell production of lipoxygenase-generated eicosanoids: a potential role in the pathophysiology of vascular changes following traumatic brain injury

The Journal of Trauma
R J HaririR H Patterson

Abstract

Acute cerebrovascular changes which occur following traumatic brain injury represent a highly complex, multifactorial pathophysiologic process which is poorly understood. It is now recognized that, under normal conditions, the brain is a source of a variety of arachidonic acid metabolites which are synthesized by both cyclooxygenase and lipoxygenase. The specific cellular source of these highly vasoactive substances remains controversial. Recent work has demonstrated that lipoxygenase products were detected by immunosensitive assay in whole brain samples from a gerbil concussive injury model, yet the production of leukotrienes could not be accounted for by cerebral vessels and their contents alone. It has been theorized that the probable source for these metabolites is the cortical neuron. We sought to elucidate whether cultured human glial cells, obtained from specimens removed at the time of surgery, are a significant source of lipoxygenase products as measured by high performance liquid chromatography (HPLC). We observed that these cells consistently produced 5, 12, and 15-HETE class eicosanoids despite failure to produce significant cyclooxygenase products. These preliminary findings are of considerable interest because the...Continue Reading

Citations

Jun 19, 2007·Neurosurgical Review·R TyagiJ Jallo
Oct 24, 2002·Neurobiology of Aging·Andis Klegeris, Patrick L McGeer
Aug 3, 2010·Antioxidants & Redox Signaling·Cameron Rink, Savita Khanna
Dec 1, 1995·Critical Care Medicine·K AsadullahR Von Baehr
Feb 14, 2016·Brain Research·Tamil Selvan AnthonymuthuHülya Bayır
Aug 10, 2012·Advances in Surgery·Eileen M Bulger, David B Hoyt
Nov 1, 1991·The Journal of Surgical Research·S R ShepardR J Hariri
Dec 18, 2015·Surgical Neurology International·Myles Dustin BooneEkkehard M Kasper
Feb 4, 1994·Brain Research·R J HaririJ B Ghajar
Feb 14, 2013·World Neurosurgery·Cattleya ThongrongSergio D Bergese
Mar 10, 2001·The Journal of Trauma·J A DoyleD B Hoyt
Jan 1, 1996·Annales Françaises D'anesthèsie Et De Rèanimation·D LugrinD Grimaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.