Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro

Neurosurgery
M HishiiK Okumura

Abstract

Intracranial malignant gliomas are sequestered from the immune system yet are associated with broad suppression of host immunocompetence. Immune system dysfunction in patients with gliomas seems to be related to inhibitory mediators produced by glioma cells. We investigated the physiological roles of glioma-derived interleukin (IL)-10 in Class II expression of monocytes, cytokine secretion from lymphocytes, and T cell proliferation in vitro. We could detect the messenger ribonucleic acid transcript of IL-10 in four gliomas by the reverse-transcribed polymerase chain reaction. Glioma-derived IL-10 greatly down-regulated human lymphocyte antigens-DR expression on monocytes. The inhibitory effect of IL-10 on interferon-gamma and tumor necrosis factor-alpha was neutralized by the anti-IL-10 monoclonal antibody; however, the inhibitory effect on IL-2 was not neutralized. Next, supernatants of glioma cells remarkably suppressed T cell proliferation in a dose-dependent fashion; however, this inhibitory effect was not restored by adding anti-IL-10 monoclonal antibodies. The supernatant also inhibited the allocytolytic activity of lymphocytes that were not neutralized by anti-IL-10 monoclonal antibody. IL-10 plays an important role in c...Continue Reading

References

Aug 1, 1992·The Journal of Surgical Research·S C WangR L Simmons
Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Jan 1, 1992·Neurosurgical Review·T NittaL Steinman
Jan 1, 1992·International Archives of Allergy and Immunology·A FontanaH W Pfister
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P PisaR Kiessling
Jan 1, 1992·Advances in Cancer Research·C J Melief
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Oct 1, 1991·Immunology Today·T RoszmanW Brooks
Jan 1, 1989·Journal of Clinical Immunology·E M FrohmanS Gupta
Dec 1, 1987·Journal of Neurosurgery·T L RoszmanL H Elliott
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·M C KuppnerN de Tribolet
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·G A GastlN H Bander
Feb 1, 1993·The Journal of Experimental Medicine·P ChomaratP Miossec

❮ Previous
Next ❯

Citations

Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·S WagnerJ C Tonn
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·C KjellmanB Widegren
May 10, 2003·Brain Research. Brain Research Reviews·Paul R WalkerPierre Yves Dietrich
Mar 1, 2000·Journal of Neuroimmunology·A R DixL A Morford
Mar 1, 2000·Journal of Neuroimmunology·E M SmithT K Hughes
Feb 11, 2000·Acta Anaesthesiologica Scandinavica·A SablotzkiG Hempelmann
Sep 13, 2002·Immunology·Paul R WalkerPierre-Yves Dietrich
Sep 22, 2006·Current Opinion in Oncology·Antoine F Carpentier, Yuxia Meng
Aug 4, 2012·PloS One·Robert L Furler, Christel H Uittenbogaart
Apr 8, 2009·Critical Reviews in Immunology·Hideho OkadaMitsugu Fujita
Nov 10, 2010·International Journal of Biological Sciences·Eui Young So, Toru Ouchi
Sep 6, 2014·Neuro-oncology·David A ReardonGlenn Dranoff
Jun 4, 2010·Stem Cell Reviews and Reports·Seung U Kim
Mar 7, 2002·International Reviews of Immunology·P H BasseR B Herberman
Oct 14, 2005·Expert Review of Anticancer Therapy·S Farzana Hussain, Amy B Heimberger
Jun 12, 2013·Expert Review of Vaccines·David A ReardonGlenn Dranoff
Nov 5, 2011·Expert Review of Anticancer Therapy·Serena PellegattaGaetano Finocchiaro
Nov 4, 2000·Expert Opinion on Investigational Drugs·B A Tjoa, M L Salgaller
Oct 6, 2004·Expert Opinion on Biological Therapy·Hideho Okada, Ian F Pollack
Sep 3, 2011·Revue neurologique·A T Szabo, A F Carpentier
Dec 1, 2009·Neurosurgery Clinics of North America·Emilia AlbesianoMichael Lim
Dec 1, 2009·Neurosurgery Clinics of North America·Gurvinder KaurCourtney Crane
Nov 21, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Isaac YangAndrew T Parsa
Dec 14, 2007·International Journal of Cancer. Journal International Du Cancer·Oliver M GrauerGosse J Adema
Oct 31, 2008·International Journal of Cancer. Journal International Du Cancer·Karin Enell SmithPeter Siesjö
Apr 28, 2004·Toxicology Letters·Joydeep MukherjeeSwapna Chaudhuri
Dec 28, 2005·Seminars in Cancer Biology·Clare Baecher-Allan, David E Anderson
Oct 4, 2005·Neurological Research·Christian W Sikorski, Maciej S Lesniak
Oct 28, 2008·Neurological Research·Necmettin TanrioverCengiz Kuday
Oct 3, 1999·The Annals of Thoracic Surgery·K O LilleheiQ Kong
Oct 19, 2010·Clinical & Developmental Immunology·Elodie VauleonVéronique Quillien
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Richard C AndersonJeffrey N Bruce
Dec 3, 2014·Biochimica Et Biophysica Acta·Thomas WurdingerTanja D de Gruijl
Oct 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Amanda L PlaconePeter C Searson
Nov 28, 2012·World Neurosurgery·Sergiy V KushchayevMark C Preul
Nov 4, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Neha KamranMaria G Castro
Nov 3, 2004·Vaccine·John R Yannelli, Joanne M Wroblewski
Oct 31, 2015·Neuro-oncology·Edjah K NduomAmy B Heimberger
Oct 31, 2015·Neuro-oncology·David A ReardonLinda Liau
Jul 5, 2006·Neurosurgical Focus·M S LesniakH Brem

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.