PMID: 8967671Dec 1, 1996Paper

Human granulocytic ehrlichiosis: a case series from a medical center in New York State

Annals of Internal Medicine
Maria E Aguero-RosenfeldJ Stephen Dumler

Abstract

Human granulocytic ehrlichiosis (HGE) is a newly described illness with few reports in the literature. To describe the clinical and laboratory feature of HGE. Case series. Tertiary care facility in New York State. 18 adult patients with HGE. Epidemiologic, clinical, and laboratory features; treatment; and outcome of patients with HGE. Patients presented with such symptoms as fever (94%) and myalgia or arthralgia (78%). Thirteen patients (71%) recalled being bitten by a tick before onset of symptoms. Leukopenia or thrombocytopenia was seen in 82% of patients, and abnormal liver enzyme levels were seen in 81%. Results of polymerase chain reaction were positive in 9 of 12 patients (75%); morulae were seen in 3 of 12 patients (25%); and the agent that causes HGE was cultured from 2 patients. All but one patient (94%) developed antibodies to Ehrlichia equi. Five patients (28%) were briefly hospitalized, and none died. All patients were successfully treated with doxycycline. The illness associated with HGE in these patients from the northeastern United States was more mild than that originally described in reports of HGE in the midwestern United States.

Citations

Dec 20, 2002·Seminars in Pediatric Infectious Diseases·Paul M Lantos, Peter J Krause
Jul 3, 1997·The New England Journal of Medicine·R B NadelmanG P Wormser
Aug 6, 1998·The New England Journal of Medicine·H W HorowitzI Schwartz
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S Bakken, J S Dumler
Sep 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G P WormserB J Luft
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E A BelongiaJ J Kazmierczak
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan S BakkenJ Stephen Dumler
Jun 14, 2003·Vector Borne and Zoonotic Diseases·Maria E Aguero-Rosenfeld
Dec 26, 2006·Vector Borne and Zoonotic Diseases·Gary P WormserMaria E Aguero-Rosenfeld
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·H W HorowitzJ M Wu
Jul 8, 2011·Clinical Microbiology Reviews·Yasuko Rikihisa
Jan 15, 2003·Clinical Microbiology Reviews·Christopher D Paddock, James E Childs
Aug 24, 2004·Infection and Immunity·Jacob W IJdo, Angel C Mueller
Aug 30, 2001·Journal of Clinical Microbiology·S E CarterR C Johnson
Jun 5, 1998·Annual Review of Public Health·D H Walker
Feb 21, 2006·Emerging Infectious Diseases·J Stephen DumlerJohan S Bakken
Mar 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S BakkenJ S Dumler
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary P WormserRobert B Nadelman
Jul 1, 2004·Expert Review of Molecular Diagnostics·J Stephen Dumler, Philippe Brouqui
Feb 3, 2009·The Veterinary Clinics of North America. Small Animal Practice·Curtis L Fritz
Dec 9, 2008·The Medical Clinics of North America·David H WalkerJ Stephen Dumler
May 12, 2007·Veterinary Parasitology·Sarah A BilleterByron L Blagburn
Sep 5, 2015·International Journal of Medical Microbiology : IJMM·Beatrix von WissmannVolker Fingerle
Oct 9, 2003·Cellular Microbiology·Jason A Carlyon, Erol Fikrig
Feb 17, 2006·Annals of the New York Academy of Sciences·J Stephen Dumler
Nov 23, 2006·Annals of the New York Academy of Sciences·Johan S Bakken, J Stephen Dumler
Sep 15, 1998·The Journal of Laboratory and Clinical Medicine·J S Bakken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
Johan S BakkenD H Walker
Annals of Internal Medicine
D B FishbeinL E Robinson
The New England Journal of Medicine
A C Steere
Proceedings of the National Academy of Sciences of the United States of America
S R TelfordD H Persing
© 2021 Meta ULC. All rights reserved