Human growth hormone promotes corneal epithelial cell migration in vitro

Cornea
Juan DingDavid A Sullivan

Abstract

Corneal wound healing is a highly regulated process that requires the proliferation and migration of epithelial cells and interactions between epithelial cells and stromal fibroblasts. Compounds that can be applied topically to the ocular surface and that have the capability of activating corneal epithelial cells to proliferate and/or migrate would be useful to promote corneal wound healing. We hypothesize that human growth hormone (HGH) will activate signal transducers and activators of transcription-5 (STAT5) signaling and promote corneal wound healing by enhancing corneal epithelial cell and fibroblast proliferation and/or migration in vitro. The purpose of this study was to test these hypotheses. We studied cell signaling, proliferation, and migration using an immortalized human corneal epithelial cell line and primary human corneal fibroblasts in vitro. We also examined whether insulin-like growth factor-1 (IGF-1), a hormone known to mediate many of HGH's growth promoting actions, may play a role in this effect. We show that HGH activates STAT5 signaling and promotes corneal epithelial cell migration in vitro. The migratory effect requires an intact communication between corneal epithelia and fibroblasts and is not mediate...Continue Reading

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Citations

Jun 6, 2015·The Ocular Surface·Barbara WirostkoJuan Ding
Sep 1, 2016·Acta Cirúrgica Brasileira·Nurten Turhan HaktanırYavuz Demir
Jan 21, 2017·Journal of Cellular Biochemistry·Yunes PanahiAmirhossein Sahebkar
Jul 1, 2017·International Journal of Molecular Sciences·Xiaobo ZhangWei Li
Aug 29, 2019·International Journal of Molecular Sciences·Lara CristóbalAndrés A Maldonado
Feb 23, 2021·Ocular Immunology and Inflammation·Anna Matysik-WoźniakRobert Rejdak
May 29, 2021·Experimental Eye Research·Nikhil G MenonTannin A Schmidt

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