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Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma

PloS One

Aug 5, 2009

Illya TietzelRey A Carabeo

Abstract

Chlamydiae are obligate intracellular pathogens that are sensitive to pro-inflammatory cytokine interferon-gamma. IFN-gamma-inducible murine p47 GTPases have been demonstrated to function in resistance to chlamydia infection in vivo and in vitro. Because the human genome does not encode...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
Infectious Agent Antigen Detection by Immunoassay With Direct Optical Observation; Chlamydia Trachomatis
Chlamydia Infections
In Vivo
Pathogenic Aspects
Immunofluorescence Assay
Tryptophan
Size
Dominant-Negative Mutation
IFNG
Paper Details
References
  • References41
  • Citations37
12345
  • References41
  • Citations37
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Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma

PloS One

Aug 5, 2009

Illya TietzelRey A Carabeo

PMID: 19652711

DOI: 10.1371/journal.pone.0006499

Abstract

Chlamydiae are obligate intracellular pathogens that are sensitive to pro-inflammatory cytokine interferon-gamma. IFN-gamma-inducible murine p47 GTPases have been demonstrated to function in resistance to chlamydia infection in vivo and in vitro. Because the human genome does not encode...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
Infectious Agent Antigen Detection by Immunoassay With Direct Optical Observation; Chlamydia Trachomatis
Chlamydia Infections
In Vivo
Pathogenic Aspects
Immunofluorescence Assay
Tryptophan
Size
Dominant-Negative Mutation
IFNG

Similar Papers Found In These Feeds

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Related Papers

Paper Details
References
  • References41
  • Citations37
12345
  • References41
  • Citations37
1234
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