Human habenula segmentation using myelin content

NeuroImage
Joo-Won KimJunqian Xu

Abstract

The habenula consists of a pair of small epithalamic nuclei located adjacent to the dorsomedial thalamus. Despite increasing interest in imaging the habenula due to its critical role in mediating subcortical reward circuitry, in vivo neuroimaging research targeting the human habenula has been limited by its small size and low anatomical contrast. In this work, we have developed an objective semi-automated habenula segmentation scheme consisting of histogram-based thresholding, region growing, geometric constraints, and partial volume estimation steps. This segmentation scheme was designed around in vivo 3 T myelin-sensitive images, generated by taking the ratio of high-resolution T1w over T2w images. Due to the high myelin content of the habenula, the contrast-to-noise ratio with the thalamus in the in vivo 3T myelin-sensitive images was significantly higher than the T1w or T2w images alone. In addition, in vivo 7 T myelin-sensitive images (T1w over T2*w ratio images) and ex vivo proton density-weighted images, along with histological evidence from the literature, strongly corroborated the in vivo 3 T habenula myelin contrast used in the proposed segmentation scheme. The proposed segmentation scheme represents a step toward a s...Continue Reading

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Citations

Apr 30, 2016·Surgical Neurology International·Serhat BaydinAlbert L Rhoton
Apr 18, 2018·Scientific Data·Wolfgang M PauliJ Michael Tyszka
Dec 4, 2019·The International Journal of Neuroscience·Tushar JawareRavindra Badgujar
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Oct 16, 2018·Frontiers in Psychiatry·Matthew SchaferGaelle E Doucet
Nov 11, 2020·Scientific Reports·Seulki YooSeung-Kyun Lee
Aug 10, 2021·Frontiers in Psychiatry·Benjamin A ElyVilma Gabbay

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