Oct 26, 2018

Human Handedness: Genetics, Microtubules, Neuropsychiatric Diseases and Brain Language Areas

BioRxiv : the Preprint Server for Biology
Akira WibergDominic Furniss

Abstract

Background: The skew in distribution of handedness is a uniquely human trait, and has fascinated researchers for centuries. The heritability of handedness is estimated at 25%, but defining genetic variants contributing to this trait has so far proved elusive. Methods: We performed GWAS of self-reported handedness in UK Biobank, a prospective cohort study of ~500,000 individuals. Furthermore, we investigated correlations between our associated SNPs and brain imaging-derived phenotypes (IDPs) from >9,000 individuals in UK Biobank, as well as between self-reported handedness and IDPs. Results: Our association study of 38,322 left-handers vs 356,567 right-handers (excluding ambidextrous participants) revealed three genome-wide significant loci (rs199512, 17q21.31, p=4.1x10-9; rs45608532, 22q11.22, p=1.4x10-8; rs13017199, 2q34, p=3.3x10-8). In the imaging study, we found strong associations between rs199512 and diffusion MRI measures mainly in white matter tracts connecting language-related brain regions (p<2.0x10-6). Direct investigation between handedness and IDPs revealed numerous associations with functional connectivity between the same language-related areas of the brain. A second GWAS of non- right handers (n=44,631) vs right...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Imaging Studies
Genome-Wide Association Study
Structure of Right Half of Body
Study
Pathogenic Aspects
TUBB gene
Pathogenesis
Genome
Genes
Tract

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.