Human health risk of ingested nanoparticles that are added as multifunctional agents to paints: an in vitro study

PloS One
Jean-Pierre KaiserPeter Wick

Abstract

Microorganisms growing on painted surfaces are not only an aesthetic problem, but also actively contribute to the weathering and deterioration of materials. A widely used strategy to combat microbial colonization is the addition of biocides to the paint. However, ecotoxic, non-degradable biocides with a broad protection range are now prohibited in Europe, so the paint industry is considering engineered nanoparticles (ENPs) as an alternative biocide. There is concern that ENPs in paint might be released in run-off water and subsequently consumed by animals and/or humans, potentially coming into contact with cells of the gastrointestinal tract and affecting the immune system. Therefore, in the present study we evaluated the cytotoxic effects of three ENPs (nanosilver, nanotitanium dioxide and nanosilicon dioxide) that have a realistic potential for use in paints in the near future. When exposed to nanotitanium dioxide and nanosilicon dioxide in concentrations up to 243 µg/mL for 48 h, neither the gastrointestinal cells (CaCo-2) nor immune system cells (Jurkat) were significantly affected. However, when exposed to nanosilver, several cell parameters were affected, but far less than by silver ions used as a control. No differences ...Continue Reading

References

Jul 1, 1992·Environmental Health Perspectives·W G Kreyling
Jun 21, 2001·Environmental Science & Technology·C Fortin, P G Campbell
Mar 6, 2002·Archives of Toxicology·R MergetT Bruening
May 22, 2003·Free Radical Biology & Medicine·Ken DonaldsonWilliam MacNee
Mar 9, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Randolph H HastingsMichael A Matthay
Mar 16, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tammie P MorganChris M Wood
Feb 4, 2006·Science·Andre NelNing Li
Apr 25, 2007·International Journal of Toxicology·Jeanne E SkeboSaber M Hussain
May 26, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Josje H E ArtsC Frieke Kuper
Jun 23, 2007·Environmental and Molecular Mutagenesis·Nicklas Raun JacobsenHåkan Wallin
May 2, 2008·Journal of Environmental Monitoring : JEM·Veli-Matti PietarinenAino Nevalainen
Jul 9, 2008·Environmental Science & Technology·Nicole C Mueller, Bernd Nowack
Dec 10, 2008·Journal of Occupational and Environmental Hygiene·Irma WellingKaarle Hämeri
Sep 19, 2009·BMC Cell Biology·P V AsharaniSuresh Valiyaveettil
Nov 26, 2009·Environmental Science & Technology·Ute SchoknechtMichael Burkhardt
May 21, 2010·Journal of Exposure Science & Environmental Epidemiology·Ismo Kalevi KoponenThomas Schneider
Jan 12, 2011·Environmental Science & Technology·Bernd NowackMurray Height
Mar 5, 2011·Particle and Fibre Toxicology·Igor PujaltéBéatrice L'Azou
Mar 15, 2011·Environment International·Claudia SomBernd Nowack
Feb 4, 2012·Particle and Fibre Toxicology·Anne Thoustrup SaberHåkan Wallin
Nov 13, 2012·Particle and Fibre Toxicology·Stijn SmuldersPeter Hm Hoet
Nov 28, 2012·The Science of the Total Environment·Jean-Pierre KaiserPeter Wick

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Citations

Mar 19, 2014·Chemosphere·Ahmed Al-KattanBernd Nowack
Feb 13, 2016·Environmental Science & Technology·Bernd NowackDanail Hristozov
Apr 9, 2016·International Journal of Molecular Sciences·Esther E Fröhlich, Eleonore Fröhlich
Jul 22, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Christie McCrackenW James Waldman
Mar 31, 2015·Regulatory Toxicology and Pharmacology : RTP·Josje H E ArtsRobert Landsiedel
Sep 7, 2016·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·P A SchulteJ Howard
Mar 30, 2019·Nanoscale Research Letters·Valeria De MatteisRosaria Rinaldi
Apr 3, 2020·International Journal of Molecular Sciences·Zannatul Ferdous, Abderrahim Nemmar
Feb 11, 2021·Environmental Science. Nano·Richard ZeppEndalkachew Sahle-Demessie
Jul 25, 2021·International Journal of Molecular Sciences·Katarzyna Dorota MorkaGabriela Bugla-Płoskońska
Sep 12, 2019·Chemical Research in Toxicology·Elijah J PetersenMatthias Roesslein

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Methods Mentioned

BETA
FCS
transmission electron microscopy
electrophoresis
ELISA

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