Human heart-type cytoplasmic fatty acid-binding protein (H-FABP) for the diagnosis of acute myocardial infarction. Clinical evaluation of H-FABP in comparison with myoglobin and creatine kinase isoenzyme MB

Clinical Chemistry and Laboratory Medicine : CCLM
F OkamotoT Tanaka

Abstract

Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight cytoplasmic protein and present abundantly in the myocardium. When the myocardium is injured, as in the case of myocardial infarction, low molecular weight cytoplasmic proteins including H-FABP are released into the circulation and H-FABP is detectable in a blood sample. We have already developed a direct sandwich-ELISA for quantification of human H-FABP using two distinct types of monoclonal antibodies specific for human H-FABP. In this study we investigated the clinical validity of H-FABP as a biochemical diagnostic marker in the early phase of acute myocardial infarction (AMI). To evaluate the diagnostic usefulness of H-FABP in the early phase of AMI, blood samples were obtained from the following patients within 12 hours after the appearance of symptoms, and serum levels of H-FABP were compared with those of conventional diagnostic markers, such as myoglobin and creatine kinase isoenzyme MB (CK-MB). Blood samples were collected from patients with confirmed AMI (n=140), patients with chest pain who were afterwards not classified as AMI by normal CK-MB levels (non-AMI) (n=49) and normal healthy volunteers (n=75). The serum concentration of H-FABP was qua...Continue Reading

References

Oct 21, 1992·Molecular and Cellular Biochemistry·A H KleineG J Van der Vusse
Jan 4, 1991·Biochimica Et Biophysica Acta·J H VeerkampR G Maatman
Jun 1, 1989·Journal of Molecular and Cellular Cardiology·A A KnowltonP Brecher
Aug 30, 1985·Chemistry and Physics of Lipids·J F GlatzJ H Veerkamp
May 1, 1981·American Journal of Clinical Pathology·S H Tsung
Jan 1, 1995·Progress in Lipid Research·J H Veerkamp, R G Maatman
Jun 27, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J IshiiK Kawamura
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F GlatzW T Hermens

❮ Previous
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Citations

Mar 1, 2007·Indian Journal of Clinical Biochemistry : IJCB·P K Nigam
Nov 15, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hideo HiroseKiyoshi Yokoi
Jan 19, 2013·Journal of Thrombosis and Thrombolysis·Christian T RuffDavid A Morrow
Jun 8, 2002·Current Cardiology Reports·Bret A Rogers, L Kristin Newby
Oct 7, 2009·Endocrine·Erdem AkbalTuncay Delibaşı
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong LiuHua Jing
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Yoshiya ToyodaYutaka Okita
Aug 7, 2008·European Heart Journal·Conor J McCannJennifer A Adgey
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi HazuiToshiaki Hanafusa
Aug 21, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Nov 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Martina ZaninottoMario Plebani
Jun 17, 2010·Biomarkers in Medicine·J A ShandD J McEneaney
Jan 1, 2009·Journal of Laboratory Physicians·Swati Gupta
Apr 15, 2010·Journal of Immunoassay & Immunochemistry·Pei-Yi XieReinhard Renneberg
May 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chien-Hua HuangWen-Jone Chen
Jul 10, 2008·Current Cardiology Reports·Frances O Wood, James A de Lemos
Feb 19, 2016·International Journal of Rheumatic Diseases·Lu ZhangGuochun Wang
Jun 17, 2010·American Journal of Clinical Pathology·Yeongsic KimByung Hak So
Jan 7, 2011·The American Journal of Emergency Medicine·C Geraldine McMahonS Peter Fitzgerald
Aug 10, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qin XuReinhard Renneberg
Mar 26, 2009·Clinical Biochemistry·Barry McDonnellRichard O'Kennedy
Jan 6, 2005·The Journal of Thoracic and Cardiovascular Surgery·Tomomi HasegawaYutaka Okita
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Jan 4, 2005·Journal of Immunological Methods·D van der VoortJ F C Glatz
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Tomomi HasegawaMasahiro Yamaguchi
Jul 25, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Atsuko Kamijo-IkemoriKenjiro Kimura
Feb 24, 2006·The American Journal of Emergency Medicine·Jamal A Alhashemi
Jul 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hitoshi NaraokaHideaki Tojo
Aug 20, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Eftihia SbarouniVassilis Voudris
Sep 23, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jul 5, 2005·Journal of the American College of Cardiology·Cheuk-Kit WongUNKNOWN HERO-2 Trial Investigators
Nov 21, 2007·Journal of the American College of Cardiology·James A de Lemos, Michelle O'Donoghue

❮ Previous
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