PMID: 8655467Jan 1, 1995Paper

Human heart-type cytoplasmic fatty acid-binding protein as an indicator of acute myocardial infarction

Heart and Vessels
K YoshimotoH Ishii

Abstract

Human heart-type cytoplasmic fatty acid-binding protein (HH-FABPc) has been proposed as an early biochemical indicator of acute myocardial infarction (AMI). However, skeletal muscles also contain HH-FABPc identical to that found in the heart. Before HH-FABPc can be clinically employed as an indicator of AMI, its content in various tissues other than the heart must be known. Accordingly, we measured the HH-FABPc content of various human muscles and organs, using a sandwich enzyme-linked immunosorbent assay (ELISA) for HH-FABPc. HH-FABPc was abundant in the ventricles (0.46 mg/g wet weight and 1.5% of the cytoplasmic protein in the left ventricle), while the atria contained slightly less HH-FABPc (0.25 mg/g wet weight and 0.7% of the cytoplasmic protein in the left atrium). Of the skeletal muscles tested, the diaphragm contained about one-quarter of the HH-FABPc content of the heart, but other skeletal muscles contained very low levels of this protein. Other than the muscles, the kidneys contained less than one-tenth of the HH-FABPc in the heart, and negligible amounts were found in the liver and small intestine. The distribution of HH-FABPc in the heart and skeletal muscles was comparable to that of cardiac-specific creatine kin...Continue Reading

References

Jul 1, 1979·European Journal of Biochemistry·T TanakaS Numa
Oct 21, 1992·Molecular and Cellular Biochemistry·A H KleineG J Van der Vusse
Feb 1, 1992·American Journal of Clinical Pathology·F S Apple
Oct 1, 1989·Journal of the American College of Cardiology·N U BangM D Clayman
Jun 1, 1989·Journal of Molecular and Cellular Cardiology·A A KnowltonP Brecher
Nov 1, 1989·Archives of Biochemistry and Biophysics·R A PeetersJ H Veerkamp
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse

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Citations

Nov 15, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hideo HiroseKiyoshi Yokoi
Oct 7, 2009·Endocrine·Erdem AkbalTuncay Delibaşı
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F GlatzW T Hermens
Jun 27, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J IshiiK Kawamura
Sep 13, 2003·Journal of Immunological Methods·Cangel P Y ChanReinhard Renneberg
Oct 17, 1998·Journal of Immunological Methods·W A KapteinR Renneberg
Sep 1, 1996·Progress in Lipid Research·J F Glatz, G J van der Vusse
Mar 19, 2004·QJM : Monthly Journal of the Association of Physicians·H A Alhadi, K A A Fox
Jun 19, 1998·British Journal of Sports Medicine·S SorichterJ F Glatz
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato FuruhashiKazuaki Shimamoto
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi HazuiToshiaki Hanafusa
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Daigo NagaharaKazuaki Shimamoto
Mar 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·K W WodzigM P van Dieijen-Visser
Jul 23, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Pierre LescuyerJean-Charles Sanchez
Jun 4, 2008·Current Opinion in Cardiology·Michelle O'Donoghue, David A Morrow
Aug 10, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qin XuReinhard Renneberg
Jul 8, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Volker StraussPaul-Georg Germann
Mar 23, 2007·Brain & Development·Tsuyoshi MatsumuraSusumu Shinno
Jan 14, 2011·Proteomics·Nisha VermaSimone Schmitz-Spanke
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Feb 17, 2019·Cellular and Molecular Life Sciences : CMLS·Kunal DhimanVeer Bala Gupta

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