PMID: 8655467Jan 1, 1995Paper

Human heart-type cytoplasmic fatty acid-binding protein as an indicator of acute myocardial infarction

Heart and Vessels
K YoshimotoH Ishii


Human heart-type cytoplasmic fatty acid-binding protein (HH-FABPc) has been proposed as an early biochemical indicator of acute myocardial infarction (AMI). However, skeletal muscles also contain HH-FABPc identical to that found in the heart. Before HH-FABPc can be clinically employed as an indicator of AMI, its content in various tissues other than the heart must be known. Accordingly, we measured the HH-FABPc content of various human muscles and organs, using a sandwich enzyme-linked immunosorbent assay (ELISA) for HH-FABPc. HH-FABPc was abundant in the ventricles (0.46 mg/g wet weight and 1.5% of the cytoplasmic protein in the left ventricle), while the atria contained slightly less HH-FABPc (0.25 mg/g wet weight and 0.7% of the cytoplasmic protein in the left atrium). Of the skeletal muscles tested, the diaphragm contained about one-quarter of the HH-FABPc content of the heart, but other skeletal muscles contained very low levels of this protein. Other than the muscles, the kidneys contained less than one-tenth of the HH-FABPc in the heart, and negligible amounts were found in the liver and small intestine. The distribution of HH-FABPc in the heart and skeletal muscles was comparable to that of cardiac-specific creatine kin...Continue Reading


Jul 1, 1979·European Journal of Biochemistry·T TanakaS Numa
Oct 21, 1992·Molecular and Cellular Biochemistry·A H KleineG J Van der Vusse
Feb 1, 1992·American Journal of Clinical Pathology·F S Apple
Oct 1, 1989·Journal of the American College of Cardiology·N U BangM D Clayman
Jun 1, 1989·Journal of Molecular and Cellular Cardiology·A A KnowltonP Brecher
Nov 1, 1989·Archives of Biochemistry and Biophysics·R A PeetersJ H Veerkamp
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse

❮ Previous
Next ❯


Nov 15, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hideo HiroseKiyoshi Yokoi
Oct 7, 2009·Endocrine·Erdem AkbalTuncay Delibaşı
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F GlatzW T Hermens
Jun 27, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J IshiiK Kawamura
Sep 13, 2003·Journal of Immunological Methods·Cangel P Y ChanReinhard Renneberg
Oct 17, 1998·Journal of Immunological Methods·W A KapteinR Renneberg
Sep 1, 1996·Progress in Lipid Research·J F Glatz, G J van der Vusse
Mar 19, 2004·QJM : Monthly Journal of the Association of Physicians·H A Alhadi, K A A Fox
Jun 19, 1998·British Journal of Sports Medicine·S SorichterJ F Glatz
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato FuruhashiKazuaki Shimamoto
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi HazuiToshiaki Hanafusa
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Daigo NagaharaKazuaki Shimamoto
Mar 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·K W WodzigM P van Dieijen-Visser
Jul 23, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Pierre LescuyerJean-Charles Sanchez
Jun 4, 2008·Current Opinion in Cardiology·Michelle O'Donoghue, David A Morrow
Aug 10, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qin XuReinhard Renneberg
Jul 8, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Volker StraussPaul-Georg Germann
Mar 23, 2007·Brain & Development·Tsuyoshi MatsumuraSusumu Shinno
Jan 14, 2011·Proteomics·Nisha VermaSimone Schmitz-Spanke
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Feb 17, 2019·Cellular and Molecular Life Sciences : CMLS·Kunal DhimanVeer Bala Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.