PMID: 7527720Jan 1, 1994Paper

Human hemoglobin conjugated to carboxylate dextran as a potential red blood cell substitute. II--Pharmacotoxicological evaluation

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
P MenuC Vigneron

Abstract

A solution of human hemoglobin bound to benzene tetracarboxylate substituted dextran, whose physicochemical characteristics are defined in part I, was evaluated in vivo as a potential red blood cell substitute. Further experiments show: - the confirmation of a lack of acute toxicity in mice and guinea pigs after injection of 12.5%, 25% and 50% of the blood mass and the absence of death in rabbits having undergone three successive 25% hemorrhagic shocks in three week intervals. A plasma half-life of 9.5 +/- 0.5 hours in 70-75% hemorrhagic shocks on guinea pigs and the absence of dex-BTC-Hb in thoracic and abdominal cavities. No tissue oedema was noticed. Total hemoglobinuria did not exceed 10% of the injected hemoglobin quantity and only involved free hemoglobin. A lack of death in 70-75% hemorrhagic shocks and survival times ranging from 10 hours to 3 days in total exchange transfusions in guinea pig experiments.

References

Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·T M Chang

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Citations

Oct 6, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·R Mehvar
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·T F Zuck, J G Riess
May 30, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Timothy N Estep
Jun 9, 2004·Biochimica Et Biophysica Acta·Yiping JiaAbdu I Alayash
Jun 9, 2004·Free Radical Biology & Medicine·Paul W BuehlerCarleton J C Hsia
Jan 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jun ZhangLian Zhao
Jan 1, 1995·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·P MenuC Vigneron
Feb 10, 1999·The American Journal of Physiology·B Faivre-FiorinaC Vigneron

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