Human hepatocellular carcinomas with a periportal phenotype have the lowest potential for early recurrence after curative resection

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Romain DésertOrlando Musso

Abstract

Hepatocellular carcinomas (HCCs) exhibit a diversity of molecular phenotypes, raising major challenges in clinical management. HCCs detected by surveillance programs at an early stage are candidates for potentially curative therapies (local ablation, resection, or transplantation). In the long term, transplantation provides the lowest recurrence rates. Treatment allocation is based on tumor number, size, vascular invasion, performance status, functional liver reserve, and the prediction of early (<2 years) recurrence, which reflects the intrinsic aggressiveness of the tumor. Well-differentiated, potentially low-aggressiveness tumors form the heterogeneous molecular class of nonproliferative HCCs, characterized by an approximate 50% β-catenin mutation rate. To define the clinical, pathological, and molecular features and the outcome of nonproliferative HCCs, we constructed a 1,133-HCC transcriptomic metadata set and validated findings in a publically available 210-HCC RNA sequencing set. We show that nonproliferative HCCs preserve the zonation program that distributes metabolic functions along the portocentral axis in normal liver. More precisely, we identified two well-differentiated, nonproliferation subclasses, namely peripor...Continue Reading

References

Jun 26, 2003·Nucleic Acids Research·Domènec FarréXavier Messeguer
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Apr 16, 2004·Molecular & Cellular Proteomics : MCP·Troels Zakarias KristiansenAkhilesh Pandey
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ju-Seog LeeSnorri S Thorgeirsson
Jun 3, 2006·Developmental Cell·Samira BenhamoucheSabine Colnot
Oct 24, 2006·The FEBS Journal·Albert BraeuningMichael Schwarz
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandrine BoyaultJessica Zucman-Rossi
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hyun Goo WooYoon Jun Kim
Apr 10, 2008·Cell Stem Cell·David J WongHoward Y Chang
Aug 15, 2008·Cancer Research·Derek Y ChiangJosep M Llovet
Oct 17, 2008·The New England Journal of Medicine·Yujin HoshidaTodd R Golub
Jun 28, 2011·Journal of Hepatology·Beatriz MínguezJosep M Llovet
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Soo Mi KimJu-Seog Lee
Dec 14, 2011·Cell·Maria HatziapostolouDimitrios Iliopoulos
Dec 14, 2011·Molecular & Cellular Proteomics : MCP·Alexandra NabaRichard O Hynes
Jan 14, 2012·The Journal of Biological Chemistry·Jessica A BonzoFrank J Gonzalez
May 29, 2012·Nature Genetics·Wing-Kin SungJohn M Luk
Jul 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anja LachenmayerJosep M Llovet
Nov 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Angélique GougeletSabine Colnot
Jan 11, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carmen Berasain, Matías A Avila
Feb 20, 2014·Diabetes·Siyu ChenChang Liu
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Taro YamashitaShuichi Kaneko
Jun 24, 2015·Gastroenterology·Jessica Zucman-RossiJosep M Llovet
Nov 19, 2015·Nucleic Acids Research·Chunlei WuAndrew I Su
Dec 5, 2015·Nature Communications·Dvir AranAtul J Butte
Apr 5, 2016·PeerJ·Florian RohartChristine A Wells
May 10, 2016·Nature Reviews. Disease Primers·Josep M LlovetGregory Gores
May 15, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandra RebouissouJessica Zucman-Rossi
Jan 6, 2017·Nature Reviews. Gastroenterology & Hepatology·Gonzalo Sapisochin, Jordi Bruix

❮ Previous
Next ❯

Citations

Jun 10, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charlotte K Y NgLuigi M Terracciano
Mar 25, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Charles NaultJessica Zucman-Rossi
Oct 7, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomonari ShimagakiYoshihiko Maehara
Jan 31, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Zhong-Zhe LinAnn-Lii Cheng
Jan 20, 2020·Molecular Oncology·Chen YangCun Wang
Nov 6, 2018·World Journal of Gastroenterology : WJG·Romain DésertOrlando Musso
Jan 20, 2019·Frontiers of Medicine·Renyu ZhangZhinan Chen
Jul 25, 2019·World Journal of Gastroenterology : WJG·Daniel NeureiterMatthias Ocker
Sep 5, 2020·American Journal of Clinical Pathology·Benjamin J Van TreeckRondell P Graham
Apr 24, 2019·World Journal of Gastroenterology : WJG·Tony El JabbourHwajeong Lee
May 16, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rui Caetano OliveiraMaria Augusta Cipriano
Oct 15, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Hao XingTian Yang
Mar 2, 2021·Seminars in Cancer Biology·Lo-Kong ChanIrene Oi-Lin Ng
Mar 6, 2021·Clinics and Research in Hepatology and Gastroenterology·Izabela ZarębskaŁukasz Szylberg
Jun 25, 2021·Nature Reviews. Gastroenterology & Hepatology·Cun WangWenxin Qin
Aug 5, 2021·JHEP Reports : Innovation in Hepatology·Shigeyuki KurosakiKazuhiko Koike
Oct 9, 2021·Journal of Cancer Research and Clinical Oncology·Aroosha Raja, Farhan Haq
Oct 8, 2021·Frontiers in Cell and Developmental Biology·Weiheng WenHong Chen
Nov 4, 2021·Hepatology Communications·Romain DesertNatalia Nieto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Journal of Hepatology
Carlos Rodríguez de LopeJordi Bruix
Liver International : Official Journal of the International Association for the Study of the Liver
Hidenori ToyodaHisashi Narimatsu
Liver International : Official Journal of the International Association for the Study of the Liver
Armin FinkenstedtBernhard Glodny
© 2022 Meta ULC. All rights reserved