Human herpes simplex virus: life cycle and development of inhibitors

Biochemistry. Biokhimii︠a︡
M K KukhanovaS N Kochetkov

Abstract

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G B ElionH J Schaeffer
Sep 1, 1978·Science·E HelgstrandB Oberg
Aug 8, 1975·Annals of the New York Academy of Sciences·G R Revankar, R K Robins
May 1, 1990·Journal of Virology·D R YagerD M Coen
Jan 1, 1989·Pharmacology & Therapeutics·B Oberg
May 1, 1983·Journal of Medicinal Chemistry·J C MartinJ P Verheyden
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·R Skaliter, I R Lehman
Jan 1, 1993·Journal of Medical Virology·G B Elion
Nov 15, 1996·The Journal of Biological Chemistry·F J Kühn, C W Knopf
Mar 10, 1997·The Journal of Cell Biology·B SodeikA Helenius
Sep 21, 2001·Nucleosides, Nucleotides & Nucleic Acids·E De ClercqJ Neyts
Apr 3, 2002·Nature Medicine·James J CruteMichael G Cordingley
Apr 3, 2002·Nature Medicine·Gerald KleymannHelga Rübsamen-Waigmann
Apr 2, 2003·Nature Reviews. Drug Discovery·Donald M Coen, Priscilla A Schaffer
Jun 21, 2003·Nucleosides, Nucleotides & Nucleic Acids·Inna L KarpenkoYury S Skoblov
Mar 1, 1959·Biochimica Et Biophysica Acta·W H PRUSOFF
Nov 25, 2003·Science·Kay GrünewaldAlasdair C Steven

❮ Previous
Next ❯

Citations

Mar 18, 2016·Scientific Reports·Xiangling WangHua Tang
Nov 18, 2016·Applied Biochemistry and Biotechnology·Esmail M El-FakharanyElrashdy M Redwan
Apr 6, 2017·Journal of Zhejiang University. Science. B·Jie ZhangBin Wei
Apr 14, 2017·Cell Death & Disease·Yu YouXiao-Yue Chen
Feb 14, 2018·Viruses·Christopher E DenesRussell J Diefenbach
Mar 21, 2019·Periodontology 2000·Jørgen Slots, Henrik Slots
Oct 27, 2018·Journal of Evidence-based Integrative Medicine·Hanan PolanskyEdan Itzkovitz
Mar 22, 2018·Frontiers in Aging Neuroscience·Steven A Harris, Elizabeth A Harris
Nov 6, 2018·Frontiers in Microbiology·Francisco J IbáñezPablo A González
May 10, 2020·Periodontology 2000·Angela R KamerMony J de Leon
Aug 26, 2020·Expert Review of Clinical Pharmacology·Kimia KardaniAzam Bolhassani
Aug 28, 2020·Frontiers in Microbiology·Liping WuXiaoyue Chen
Aug 28, 2020·Eye·Daniel Sibley, Daniel F P Larkin
Dec 19, 2019·Frontiers in Microbiology·Fatai S OladunniThomas M Chambers
Jul 4, 2020·Scientific Reports·Ibrahim T HagagBenedikt B Kaufer
Apr 30, 2020·Archives of Virology·Laurita BoffCláudia Maria Oliveira Simões
Jun 20, 2020·Human Gene Therapy·Lea KrutzkeStefan Kochanek
Mar 3, 2020·Frontiers in Microbiology·Diana M ÁlvarezPablo A González
Sep 24, 2020·Nature Communications·Junqing SunPeiyi Wang
Dec 15, 2019·Clinical Reviews in Allergy & Immunology·Alexia DamourCharles Bodet
Oct 6, 2020·Frontiers in Microbiology·Estefanía CastilloPablo A González
Nov 25, 2020·Journal of Drug Targeting·Dana ElkhalifaAshraf Khalil
Dec 2, 2020·Viruses·Sabina AndreuJosé Antonio López-Guerrero
Oct 30, 2019·Microorganisms·Raghuram KogantiDeepak Shukla
Feb 16, 2021·Frontiers in Immunology·Jun ZhaoPinghui Feng
May 21, 2021·Frontiers in Immunology·Luisa F DuartePablo A González
Aug 29, 2021·Pharmaceuticals·Nour Mammari On Behalf Of The Oemonom
Aug 28, 2021·Materials·Yabing ChenHeng-Bo Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.